Kin-Driver - A human kinase database with driver mutations

EGFR_HUMAN

Showing all mutations

UniProt id	Mutation	Type	Relative Frequency	Validation Status	Reference	MSA	PDB	Number of Samples
EGFR_HUMAN	V689M	missense	0.0379262	Activating	EGFR database	No	Yes	1
EGFR_HUMAN	G696E	missense	0.0379262	Activating	EGFR database	No	Yes	1
EGFR_HUMAN	P699S	missense	0.0758524	Activating	EGFR database	No	Yes	2
EGFR_HUMAN	N700D	missense	0.0379262	Activating	EGFR database	No	Yes	1
EGFR_HUMAN	Q701*	nonsense	0.0379262	Activating	EGFR database	No	Yes	1
EGFR_HUMAN	E709A	missense	1.21364	Activating	EGFR database	No	Yes	32
EGFR_HUMAN	E709G	missense	0.606819	Activating	EGFR database	No	Yes	16
EGFR_HUMAN	E709K	missense	1.78253	Activating	EGFR database	No	Yes	47
EGFR_HUMAN	E709V	missense	0.265483	Activating	EGFR database	No	Yes	7
EGFR_HUMAN	G719A	missense	6.82671	Activating	EGFR database	Yes	Yes	180
EGFR_HUMAN	G719C	missense	3.10995	Activating	EGFR database	Yes	Yes	82
EGFR_HUMAN	G719S	missense	5.27174	Activating	EGFR database	Yes	Yes	139
EGFR_HUMAN	S720F	missense	0.530967	Activating	EGFR database	Yes	Yes	14
EGFR_HUMAN	K745_A750del	deletion	0.834376	Activating	EGFR database	Yes	Yes	22
EGFR_HUMAN	K745_E749del	deletion	0.530967	Activating	EGFR database	Yes	Yes	14
EGFR_HUMAN	E746_A750>P	indel	0.02	Activating	EGFR database	Yes	Yes	0
EGFR_HUMAN	E746_S752>A	indel	0.341336	Activating	EGFR database	Yes	Yes	9
EGFR_HUMAN	E746_S752>V	indel	4.85455	Activating	EGFR database	Yes	Yes	128
EGFR_HUMAN	E746_T751>A	indel	1.82046	Activating	EGFR database	Yes	Yes	48
EGFR_HUMAN	E746_T751>D	indel	0	Activating	EGFR database	Yes	Yes	0
EGFR_HUMAN	E746_T751>I	indel	0.265483	Activating	EGFR database	Yes	Yes	7
EGFR_HUMAN	E746_T751>V	indel	0.455114	Activating	EGFR database	Yes	Yes	12
EGFR_HUMAN	E746_A750>IP	indel	0.30341	Activating	EGFR database	Yes	Yes	8
EGFR_HUMAN	E746_A750del	deletion	132.173	Activating	EGFR database	Yes	Yes	3485
EGFR_HUMAN	E746_E749del	deletion	0.493041	Activating	EGFR database	Yes	Yes	13
EGFR_HUMAN	E746_R748del	deletion	0.0758524	Activating	16043828	Yes	Yes	2
EGFR_HUMAN	E746_S752del	deletion	0.682672	Activating	EGFR database	Yes	Yes	18
EGFR_HUMAN	E746_T751>VA	indel	0.30341	Activating	EGFR database	Yes	Yes	8
EGFR_HUMAN	E746_T751del	deletion	1.28949	Activating	EGFR database	Yes	Yes	34
EGFR_HUMAN	L747S	missense	0.568893	Activating	16043828	Yes	Yes	15
EGFR_HUMAN	L747_A750>P	indel	6.86464	Activating	EGFR database	Yes	Yes	181
EGFR_HUMAN	L747_E749>P	indel	0.0379262	Activating	EGFR database	Yes	Yes	1
EGFR_HUMAN	L747_P753>P	indel	0	Activating	EGFR database	Yes	Yes	0
EGFR_HUMAN	L747_P753>Q	indel	0.910229	Activating	EGFR database	Yes	Yes	24
EGFR_HUMAN	L747_P753>S	indel	11.1503	Activating	EGFR database	Yes	Yes	294
EGFR_HUMAN	L747_T751>P	indel	1.7446	Activating	EGFR database	Yes	Yes	46
EGFR_HUMAN	L747_T751>Q	indel	0.265483	Activating	EGFR database	Yes	Yes	7
EGFR_HUMAN	L747_T751>S	indel	0.493041	Activating	EGFR database	Yes	Yes	13
EGFR_HUMAN	L747_E749del	deletion	1.06193	Activating	EGFR database	Yes	Yes	28
EGFR_HUMAN	L747_P753del	deletion	1.28949	Activating	EGFR database	Yes	Yes	34
EGFR_HUMAN	L747_S752del	deletion	3.56506	Activating	EGFR database	Yes	Yes	94
EGFR_HUMAN	L747_T751del	deletion	7.43353	Activating	EGFR database	Yes	Yes	196
EGFR_HUMAN	R748_P753del	deletion	0.0758524	Activating	16043828	Yes	Yes	2
EGFR_HUMAN	E749Q	missense	0	Activating	16043828	Yes	Yes	0
EGFR_HUMAN	E750P	missense	0	Activating	16043828	Yes	Yes	0
EGFR_HUMAN	T751_I759>N	indel	0.644745	Activating	EGFR database	Yes	Yes	17
EGFR_HUMAN	T751_I759>S	indel	0.113779	Activating	EGFR database	Yes	Yes	3
EGFR_HUMAN	S752_I759del	deletion	1.02401	Activating	EGFR database	Yes	Yes	27
EGFR_HUMAN	V765M	missense	0.341336	Activating	EGFR database	Yes	Yes	9
EGFR_HUMAN	S768I	missense	9.32984	Activating	EGFR database	Yes	Yes	246
EGFR_HUMAN	R776C	missense	0.30341	Activating	EGFR database	Yes	Yes	8
EGFR_HUMAN	R776H	missense	0.682672	Activating	EGFR database	Yes	Yes	18
EGFR_HUMAN	G779F	missense	0.113779	Activating	EGFR database	Yes	Yes	3
EGFR_HUMAN	T790M	missense	46.763	Activating	17332364	Yes	Yes	1233
EGFR_HUMAN	K806E	missense	0.151705	Activating	EGFR database	Yes	Yes	4
EGFR_HUMAN	Q812R	missense	0.0379262	Activating	EGFR database	Yes	Yes	1
EGFR_HUMAN	L814P	missense	0.113779	Activating	EGFR database	Yes	Yes	3
EGFR_HUMAN	L833V	missense	1.32742	Activating	EGFR database	Yes	Yes	35
EGFR_HUMAN	R836C	missense	0.189631	Activating	EGFR database	Yes	Yes	5
EGFR_HUMAN	L838P	missense	0.151705	Activating	EGFR database	Yes	Yes	4
EGFR_HUMAN	A839T	missense	0.189631	Activating	EGFR database	Yes	Yes	5
EGFR_HUMAN	V843I	missense	0.417188	Activating	EGFR database	Yes	Yes	11
EGFR_HUMAN	K846R	missense	0.0379262	Activating	EGFR database	Yes	Yes	1
EGFR_HUMAN	D855G	missense	0.0379262	Activating	EGFR database	Yes	Yes	1
EGFR_HUMAN	F856L	missense	0.113779	Activating	EGFR database	Yes	Yes	3
EGFR_HUMAN	G857R	missense	0.189631	Activating	EGFR database	Yes	Yes	5
EGFR_HUMAN	L858R	missense	377.707	Activating	EGFR database	Yes	Yes	9959
EGFR_HUMAN	L861Q	missense	14.7533	Activating	EGFR database	Yes	Yes	389
EGFR_HUMAN	L861R	missense	0.606819	Activating	EGFR database	Yes	Yes	16
EGFR_HUMAN	G863D	missense	0.265483	Activating	EGFR database	Yes	Yes	7
EGFR_HUMAN	E865L	missense	0	Activating	EGFR database	Yes	Yes	0