Kin-Driver - A human kinase database with driver mutations



EGFR_HUMAN E709K  

UniProt Pfam

Validation Status: Activating

Relative Frequency: 1.78253

Reference : EGFR database

View All Samples for this mutation


Central Moving Average Plot

Central Moving Average plot is not available as this mutation is not in the kinase domain.


3D Structures - Mapping the mutation onto a PDB structure

PDB idDescriptionResolutionSPACI Score
3POZ_Aegfr kinase domain complexed with tak-2851.50.598043
2RGP_Astructure of egfr in complex with hydrazone, a potent dual inhibitor20.398807
3VJN_Acrystal structure of the mutated egfr kinase domain (g719s/t complex with amppnp.2.340.357415
1XKK_Aegfr kinase domain complexed with a quinazoline inhibitor- gw5720162.40.349657
3BEL_Ax-ray structure of egfr in complex with oxime inhibitor2.30.334124
3UG2_Acrystal structure of the mutated egfr kinase domain (g719s/t complex with gefitinib2.50.32858
2EB2_Acrystal structure of mutated egfr kinase domain (g719s)2.50.326237
2ITV_Acrystal structure of egfr kinase domain l858r mutation in complex with amp-pnp2.470.319794
2ITN_Acrystal structure of egfr kinase domain g719s mutation in complex with amp-pnp2.470.319681
3VJO_Acrystal structure of the wild-type egfr kinase domain in com amppnp.2.640.304627
2GS6_Acrystal structure of the active egfr kinase domain in complex with an atp analog-peptide conjugate2.60.296067
4G5J_Acrystal structure of egfr kinase in complex with bibw29922.80.292509
2ITQ_Acrystal structure of egfr kinase domain g719s mutation in complex with afn9412.680.282167
2EB3_Acrystal structure of mutated egfr kinase domain (l858r) in c with amppnp2.840.281051
4HJO_Acrystal structure of the inactive egfr tyrosine kinase domai erlotinib2.750.277641
2ITZ_Acrystal structure of egfr kinase domain l858r mutation in complex with iressa2.720.273453
2ITP_Acrystal structure of egfr kinase domain g719s mutation in complex with aee7882.740.27047
2GS2_Acrystal structure of the active egfr kinase domain2.80.267665
3GOP_Acrystal structure of the egf receptor juxtamembrane and kina2.80.267089
2GS7_Acrystal structure of the inactive egfr kinase domain in complex with amp-pnp2.60.265955
2GS7_Bcrystal structure of the inactive egfr kinase domain in complex with amp-pnp2.60.265955
2ITW_Acrystal structure of egfr kinase domain in complex with afn9412.880.264271
1M14_Atyrosine kinase domain from epidermal growth factor receptor2.60.262527
3UG1_Acrystal structure of the mutated egfr kinase domain (g719s/t the apo form2.750.262309
2ITT_Acrystal structure of egfr kinase domain l858r mutation in complex with aee7882.730.261026
2ITU_Acrystal structure of egfr kinase domain l858r mutation in complex with afn9412.80.258994
3LZB_Degfr kinase domain complexed with an imidazo[2,1-b]thiazole2.70.258584
3LZB_Aegfr kinase domain complexed with an imidazo[2,1-b]thiazole2.70.258584
3LZB_Begfr kinase domain complexed with an imidazo[2,1-b]thiazole2.70.258584
3LZB_Cegfr kinase domain complexed with an imidazo[2,1-b]thiazole2.70.258584
1M17_Aepidermal growth factor receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor erlotinib2.60.249629
2ITX_Acrystal structure of egfr kinase domain in complex with amp- pnp2.980.24909
2J5F_Acrystal structure of egfr kinase domain in complex with an irreversible inhibitor 34-jab30.242153
3GT8_Acrystal structure of the inactive egfr kinase domain in complex with amp-pnp2.960.225998
3GT8_Bcrystal structure of the inactive egfr kinase domain in complex with amp-pnp2.960.225998
3GT8_Dcrystal structure of the inactive egfr kinase domain in complex with amp-pnp2.960.225998
3IKA_Acrystal structure of egfr 696-1022 t790m mutant covalently binding to wz40022.90.224373
2RFE_Acrystal structure of the complex between the egfr kinase domain and a mig6 peptide2.90.22286
2RFE_Dcrystal structure of the complex between the egfr kinase domain and a mig6 peptide2.90.22286
2JIT_Bcrystal structure of egfr kinase domain t790m mutation3.10.216522
2J5E_Acrystal structure of egfr kinase domain in complex with an irreversible inhibitor 13-jab3.10.21627
2J6M_Acrystal structure of egfr kinase domain in complex with aee7883.10.209579
2JIU_Bcrystal structure of egfr kinase domain t790m mutation in complex with aee7883.050.198567
2ITO_Acrystal structure of egfr kinase domain g719s mutation in complex with iressa3.250.193627
4G5P_Acrystal structure of egfr kinase t790m in complex with bibw23.170.181471
4G5P_Bcrystal structure of egfr kinase t790m in complex with bibw23.170.181471
2ITY_Acrystal structure of egfr kinase domain in complex with iressa3.420.177366
2RFD_Acrystal structure of the complex between the egfr kinase domain and a mig6 peptide3.60.133577
2RF9_Acrystal structure of the complex between the egfr kinase domain and a mig6 peptide3.50.0714469
2JIV_Acrystal structure of egfr kinase domain t790m mutation in compex with hki-2723.50.0126281
2JIV_Bcrystal structure of egfr kinase domain t790m mutation in compex with hki-2723.50.0126281
1Z9I_Aa structural model for the membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor0.00122381
4I20_A
4I21_A
4I21_B
4I22_A
4I23_A
4I24_A
3W2O_A
4I24_B
3W2P_A
3W2Q_A
3W2R_A
3W2S_A
4I1Z_A

PDB: 3POZ_A

Resolution: 1.5 Å
"egfr kinase domain complexed with tak-285"
UniProt residue Number PDB residue Number
709709
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