Kin-Driver - A human kinase database with driver mutations



EGFR_HUMAN G696E  

UniProt Pfam

Validation Status: Activating

Relative Frequency: 0.0379262

Reference : EGFR database

View All Samples for this mutation


Central Moving Average Plot

Central Moving Average plot is not available as this mutation is not in the kinase domain.


3D Structures - Mapping the mutation onto a PDB structure

PDB idDescriptionResolutionSPACI Score
2EB2_Acrystal structure of mutated egfr kinase domain (g719s)2.50.326237
2ITV_Acrystal structure of egfr kinase domain l858r mutation in complex with amp-pnp2.470.319794
2ITN_Acrystal structure of egfr kinase domain g719s mutation in complex with amp-pnp2.470.319681
3VJO_Acrystal structure of the wild-type egfr kinase domain in com amppnp.2.640.304627
2GS6_Acrystal structure of the active egfr kinase domain in complex with an atp analog-peptide conjugate2.60.296067
4G5J_Acrystal structure of egfr kinase in complex with bibw29922.80.292509
2EB3_Acrystal structure of mutated egfr kinase domain (l858r) in c with amppnp2.840.281051
2GS2_Acrystal structure of the active egfr kinase domain2.80.267665
3GOP_Acrystal structure of the egf receptor juxtamembrane and kina2.80.267089
2ITW_Acrystal structure of egfr kinase domain in complex with afn9412.880.264271
1M14_Atyrosine kinase domain from epidermal growth factor receptor2.60.262527
2ITU_Acrystal structure of egfr kinase domain l858r mutation in complex with afn9412.80.258994
1M17_Aepidermal growth factor receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor erlotinib2.60.249629
2J5F_Acrystal structure of egfr kinase domain in complex with an irreversible inhibitor 34-jab30.242153
3IKA_Acrystal structure of egfr 696-1022 t790m mutant covalently binding to wz40022.90.224373
2J5E_Acrystal structure of egfr kinase domain in complex with an irreversible inhibitor 13-jab3.10.21627
2JIU_Bcrystal structure of egfr kinase domain t790m mutation in complex with aee7883.050.198567
2ITO_Acrystal structure of egfr kinase domain g719s mutation in complex with iressa3.250.193627
4G5P_Acrystal structure of egfr kinase t790m in complex with bibw23.170.181471
1Z9I_Aa structural model for the membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor0.00122381
4I23_A

PDB: 2EB2_A

Resolution: 2.5 Å
"crystal structure of mutated egfr kinase domain (g719s)"
UniProt residue Number PDB residue Number
696696
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