mutant_id mutation pfam_domain_id uniprot_id rel_freq abs_freq disease_id validation from_res_n to_res_n mut_type gene_sample_count PGFRA_HUMAN.D842_D846>E D842_D846>E PGFRA_HUMAN/593-950 PGFRA_HUMAN 1.46771037181996 3 0 Activating 842 846 indel 2044 PGFRA_HUMAN.H845_N848>P H845_N848>P PGFRA_HUMAN/593-950 PGFRA_HUMAN 1.46771037181996 3 0 Activating 845 848 indel 2044 PGFRA_HUMAN.V561D V561D null PGFRA_HUMAN 31.3111545988258 64 0 Activating 561 561 missense 2044 PGFRA_HUMAN.Y849S Y849S PGFRA_HUMAN/593-950 PGFRA_HUMAN 0.978473581213307 2 1 Activating 849 849 missense 2044 PGFRA_HUMAN.N659Y N659Y PGFRA_HUMAN/593-950 PGFRA_HUMAN 2.44618395303327 5 0 Activating 659 659 missense 2044 PGFRA_HUMAN.N659K N659K PGFRA_HUMAN/593-950 PGFRA_HUMAN 13.2093933463796 27 0 Activating 659 659 missense 2044 PGFRA_HUMAN.S566_E571>R S566_E571>R null PGFRA_HUMAN 24.4618395303327 50 0 Activating 566 571 indel 2044 PGFRA_HUMAN.S566_E571>K S566_E571>K null PGFRA_HUMAN 3.91389432485323 8 0 Activating 566 571 indel 2044 PGFRA_HUMAN.D842V D842V PGFRA_HUMAN/593-950 PGFRA_HUMAN 277.886497064579 568 0 Activating 842 842 missense 2044 PGFRA_HUMAN.I843_S847>T I843_S847>T PGFRA_HUMAN/593-950 PGFRA_HUMAN 4.89236790606654 10 0 Activating 843 847 indel 2044 PGFRA_HUMAN.D842Y D842Y PGFRA_HUMAN/593-950 PGFRA_HUMAN 8.80626223091977 18 0 Activating 842 842 missense 2044 PGFRA_HUMAN.D842_D846>H D842_D846>H PGFRA_HUMAN/593-950 PGFRA_HUMAN 1.95694716242661 4 0 Activating 842 846 indel 2044 PGFRA_HUMAN.Y849C Y849C PGFRA_HUMAN/593-950 PGFRA_HUMAN 2.93542074363992 6 0 Activating 849 849 missense 2044 JAK2_HUMAN.T875N T875N JAK2_HUMAN/849-1123 JAK2_HUMAN 0.0800384184408516 4 2 Activating 875 875 missense 49976 JAK2_HUMAN.I540_E543>MK I540_E543>MK null JAK2_HUMAN 0.160076836881703 8 2 Activating 540 543 indel 49976 JAK2_HUMAN.R564L R564L JAK2_HUMAN/545-805 JAK2_HUMAN 0.100048023051065 5 2 Activating 564 564 missense 49976 JAK2_HUMAN.F537_K539>L F537_K539>L null JAK2_HUMAN 0.400192092204258 20 2 Activating 537 539 indel 49976 JAK2_HUMAN.H538_K539>QL H538_K539>QL null JAK2_HUMAN 0.200096046102129 10 2 Activating 538 539 indel 49976 JAK2_HUMAN.R541_E543>K R541_E543>K null JAK2_HUMAN 0.340163278373619 17 2 Activating 541 543 indel 49976 JAK2_HUMAN.H538_K539>L H538_K539>L null JAK2_HUMAN 0.360172882983832 18 2 Activating 538 539 indel 49976 JAK2_HUMAN.R683G R683G JAK2_HUMAN/545-805 JAK2_HUMAN 1.52072995037618 76 2 Activating 683 683 missense 49976 JAK2_HUMAN.V617F V617F JAK2_HUMAN/545-805 JAK2_HUMAN 931.4270850008 46549 2 Activating 617 617 missense 49976 FGFR2_HUMAN.N549K N549K FGFR2_HUMAN/481-757 FGFR2_HUMAN 83.0985915492958 59 3 Activating 549 549 missense 710 FGFR2_HUMAN.Y375C Y375C null FGFR2_HUMAN 28.169014084507 20 3 Activating 375 375 missense 710 FGFR2_HUMAN.N549H N549H FGFR2_HUMAN/481-757 FGFR2_HUMAN 12.6760563380282 9 3 Activating 549 549 missense 710 FGFR2_HUMAN.S372C S372C null FGFR2_HUMAN 1.40845070422535 1 3 Activating 372 372 missense 710 FGFR2_HUMAN.K659N K659N FGFR2_HUMAN/481-757 FGFR2_HUMAN 4.22535211267606 3 3 Activating 659 659 missense 710 FGFR2_HUMAN.N549T N549T FGFR2_HUMAN/481-757 FGFR2_HUMAN 2.8169014084507 2 4 Activating 549 549 missense 710 FGFR2_HUMAN.S252W S252W null FGFR2_HUMAN 173.239436619718 123 5 Activating 252 252 missense 710 FGFR2_HUMAN.K641R K641R FGFR2_HUMAN/481-757 FGFR2_HUMAN 1.40845070422535 1 4 Activating 641 641 missense 710 FGFR2_HUMAN.K659E K659E FGFR2_HUMAN/481-757 FGFR2_HUMAN 22.5352112676056 16 3 Activating 659 659 missense 710 MP2K1_HUMAN.Y130C Y130C MP2K1_HUMAN/68-361 MP2K1_HUMAN 8.87573964497041 3 6 Activating 130 130 missense 338 STK33_HUMAN.F323L F323L STK33_HUMAN/116-381 STK33_HUMAN 10.8108108108108 2 7 Activating 323 323 missense 185 KIT_HUMAN.W557C W557C null KIT_HUMAN 1.42298114549982 12 0 Activating 557 557 missense 8433 KIT_HUMAN.K581_W582insDPTQLPYDH K581_W582insDPTQLPYDH null KIT_HUMAN 0.118581762124985 1 0 Activating 581 582 insertion 8433 KIT_HUMAN.K550_V555>I K550_V555>I null KIT_HUMAN 0.711490572749911 6 0 Activating 550 555 indel 8433 KIT_HUMAN.V559A V559A null KIT_HUMAN 9.13079568362386 77 0 Activating 559 559 missense 8433 KIT_HUMAN.F591_G592ins15 F591_G592ins15 KIT_HUMAN/589-924 KIT_HUMAN 0.711490572749911 6 0 Activating 591 592 insertion 8433 KIT_HUMAN.W557_K558>E W557_K558>E null KIT_HUMAN 0.948654096999881 8 0 Activating 557 558 indel 8433 KIT_HUMAN.M552_V559>I M552_V559>I null KIT_HUMAN 1.18581762124985 10 0 Activating 552 559 indel 8433 KIT_HUMAN.V560E V560E null KIT_HUMAN 2.72738052887466 23 0 Activating 560 560 missense 8433 KIT_HUMAN.W557_K558>F W557_K558>F null KIT_HUMAN 0.23716352424997 2 0 Activating 557 558 indel 8433 KIT_HUMAN.W557G W557G null KIT_HUMAN 7.11490572749911 60 0 Activating 557 557 missense 8433 KIT_HUMAN.W557S W557S null KIT_HUMAN 0.474327048499941 4 0 Activating 557 557 missense 8433 KIT_HUMAN.D816Y D816Y KIT_HUMAN/589-924 KIT_HUMAN 12.2139214988735 103 8 Activating 816 816 missense 8433 KIT_HUMAN.D816V D816V KIT_HUMAN/589-924 KIT_HUMAN 192.458199928851 1623 8 Activating 816 816 missense 8433 KIT_HUMAN.Y553_E561>LK Y553_E561>LK null KIT_HUMAN 0.23716352424997 2 0 Activating 553 561 indel 8433 KIT_HUMAN.R586_N587ins13 R586_N587ins13 null KIT_HUMAN 0.711490572749911 6 0 Activating 586 587 insertion 8433 KIT_HUMAN.K558E K558E null KIT_HUMAN 0.711490572749911 6 0 Activating 558 558 missense 8433 KIT_HUMAN.P585_R586ins12 P585_R586ins12 null KIT_HUMAN 1.18581762124985 10 0 Activating 585 586 insertion 8433 KIT_HUMAN.E554_D572>A E554_D572>A null KIT_HUMAN 0.355745286374956 3 0 Activating 554 572 indel 8433 KIT_HUMAN.H580_K581insPYDH H580_K581insPYDH null KIT_HUMAN 0.474327048499941 4 0 Activating 580 581 insertion 8433 KIT_HUMAN.K558N K558N null KIT_HUMAN 1.77872643187478 15 0 Activating 558 558 missense 8433 KIT_HUMAN.D579_H580insIDPTQLPYD D579_H580insIDPTQLPYD null KIT_HUMAN 0.830072334874896 7 0 Activating 579 580 insertion 8433 KIT_HUMAN.V559G V559G null KIT_HUMAN 6.28483339262421 53 0 Activating 559 559 missense 8433 KIT_HUMAN.V560G V560G null KIT_HUMAN 4.50610696074944 38 0 Activating 560 560 missense 8433 KIT_HUMAN.W557R W557R null KIT_HUMAN 16.364283173248 138 0 Activating 557 557 missense 8433 KIT_HUMAN.Y503_F504insAY Y503_F504insAY null KIT_HUMAN 59.6466263488675 503 0 Activating 503 504 insertion 8433 KIT_HUMAN.P585_R586insLPYDHKWEFP P585_R586insLPYDHKWEFP null KIT_HUMAN 0.118581762124985 1 0 Activating 585 586 insertion 8433 KIT_HUMAN.L589_S590ins15 L589_S590ins15 KIT_HUMAN/589-924 KIT_HUMAN 0.23716352424997 2 0 Activating 589 590 insertion 8433 KIT_HUMAN.K558Q K558Q null KIT_HUMAN 0.23716352424997 2 0 Activating 558 558 missense 8433 KIT_HUMAN.W557_K558>C W557_K558>C null KIT_HUMAN 0.23716352424997 2 0 Activating 557 558 indel 8433 KIT_HUMAN.L576P L576P null KIT_HUMAN 27.3923870508716 231 0 Activating 576 576 missense 8433 KIT_HUMAN.V560D V560D null KIT_HUMAN 23.5977706628721 199 0 Activating 560 560 missense 8433 KIT_HUMAN.P551_M552>L P551_M552>L null KIT_HUMAN 0.830072334874896 7 0 Activating 551 552 indel 8433 KIT_HUMAN.K558_Y570>N K558_Y570>N null KIT_HUMAN 0.23716352424997 2 0 Activating 558 570 indel 8433 KIT_HUMAN.E583_F584insPYDHKWE E583_F584insPYDHKWE null KIT_HUMAN 0.23716352424997 2 0 Activating 583 584 insertion 8433 KIT_HUMAN.D816H D816H KIT_HUMAN/589-924 KIT_HUMAN 11.9767579746235 101 8 Activating 816 816 missense 8433 KIT_HUMAN.Q556_V559>H Q556_V559>H null KIT_HUMAN 0.948654096999881 8 0 Activating 556 559 indel 8433 KIT_HUMAN.W557F W557F null KIT_HUMAN 0.118581762124985 1 0 Activating 557 557 missense 8433 KIT_HUMAN.M552_E554>K M552_E554>K null KIT_HUMAN 1.06723585912487 9 0 Activating 552 554 indel 8433 KIT_HUMAN.V559D V559D null KIT_HUMAN 29.4082770069963 248 0 Activating 559 559 missense 8433 KIT_HUMAN.K642E K642E KIT_HUMAN/589-924 KIT_HUMAN 16.8386102217479 142 8 Activating 642 642 missense 8433 FLT3_HUMAN.F605_P606insQYDLKWEF F605_P606insQYDLKWEF null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.F590_Y591ins13 F590_Y591ins13 null FLT3_HUMAN 0.117931481809069 2 9 Activating 590 591 insertion 16959 FLT3_HUMAN.W603_E604insREYEYDLKW W603_E604insREYEYDLKW null FLT3_HUMAN 0.117931481809069 2 9 Activating 603 604 insertion 16959 FLT3_HUMAN.Y591_V592ins10 Y591_V592ins10 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 591 592 insertion 16959 FLT3_HUMAN.N841H N841H FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 841 841 missense 16959 FLT3_HUMAN.R607_E608ins23 R607_E608ins23 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 607 608 insertion 16959 FLT3_HUMAN.D593_F594ins13 D593_F594ins13 null FLT3_HUMAN 0.176897222713603 3 9 Activating 593 594 insertion 16959 FLT3_HUMAN.L601_K602ins11 L601_K602ins11 null FLT3_HUMAN 0.176897222713603 3 9 Activating 601 602 insertion 16959 FLT3_HUMAN.L610_E611ins18 L610_E611ins18 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 610 611 insertion 16959 FLT3_HUMAN.D593_F594ins12 D593_F594ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 593 594 insertion 16959 FLT3_HUMAN.Y597_E598insDYVDFREY Y597_E598insDYVDFREY null FLT3_HUMAN 1.7100064862315 29 9 Activating 597 598 insertion 16959 FLT3_HUMAN.R607_E608ins12 R607_E608ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 607 608 insertion 16959 FLT3_HUMAN.D600_L601ins10 D600_L601ins10 null FLT3_HUMAN 0.176897222713603 3 9 Activating 600 601 insertion 16959 FLT3_HUMAN.E611_F612ins27 E611_F612ins27 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 611 612 insertion 16959 FLT3_HUMAN.E611_F612ins24 E611_F612ins24 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 611 612 insertion 16959 FLT3_HUMAN.D600_L601ins24 D600_L601ins24 null FLT3_HUMAN 0.117931481809069 2 9 Activating 600 601 insertion 16959 FLT3_HUMAN.Y597_E598ins16 Y597_E598ins16 null FLT3_HUMAN 0.117931481809069 2 9 Activating 597 598 insertion 16959 FLT3_HUMAN.F594_R595insSNEYFYVDF F594_R595insSNEYFYVDF null FLT3_HUMAN 0.117931481809069 2 9 Activating 594 595 insertion 16959 FLT3_HUMAN.Y599_D600ins13 Y599_D600ins13 null FLT3_HUMAN 0.117931481809069 2 9 Activating 599 600 insertion 16959 FLT3_HUMAN.E598_Y599ins14 E598_Y599ins14 null FLT3_HUMAN 0.176897222713603 3 9 Activating 598 599 insertion 16959 FLT3_HUMAN.F612_G613insPRENLEF F612_G613insPRENLEF FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 612 613 insertion 16959 FLT3_HUMAN.Y599_D600insVDFREYEY Y599_D600insVDFREYEY null FLT3_HUMAN 0.117931481809069 2 9 Activating 599 600 insertion 16959 FLT3_HUMAN.E596_Y597ins23 E596_Y597ins23 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 596 597 insertion 16959 FLT3_HUMAN.F590_Y591>GD F590_Y591>GD null FLT3_HUMAN 0.0589657409045345 1 9 Activating 590 591 indel 16959 FLT3_HUMAN.N609_L610ins17 N609_L610ins17 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 609 610 insertion 16959 FLT3_HUMAN.L601_K602insGEYDL L601_K602insGEYDL null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.W603_E604ins10 W603_E604ins10 null FLT3_HUMAN 0.176897222713603 3 9 Activating 603 604 insertion 16959 FLT3_HUMAN.Y597_E598ins21 Y597_E598ins21 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 597 598 insertion 16959 FLT3_HUMAN.Y597_E598ins18 Y597_E598ins18 null FLT3_HUMAN 0.176897222713603 3 9 Activating 597 598 insertion 16959 FLT3_HUMAN.Y599_D600insEYEYEYEY Y599_D600insEYEYEYEY null FLT3_HUMAN 0.235862963618138 4 9 Activating 599 600 insertion 16959 FLT3_HUMAN.E604_F605ins26 E604_F605ins26 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 604 605 insertion 16959 FLT3_HUMAN.V592_D593ins11 V592_D593ins11 null FLT3_HUMAN 0.176897222713603 3 9 Activating 592 593 insertion 16959 FLT3_HUMAN.E596_Y597ins19 E596_Y597ins19 null FLT3_HUMAN 0.235862963618138 4 9 Activating 596 597 insertion 16959 FLT3_HUMAN.Y599_D600ins11 Y599_D600ins11 null FLT3_HUMAN 0.117931481809069 2 9 Activating 599 600 insertion 16959 FLT3_HUMAN.F605_P606ins19 F605_P606ins19 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.K602_W603insFEIIFIFSEI K602_W603insFEIIFIFSEI null FLT3_HUMAN 0.0589657409045345 1 9 Activating 602 603 insertion 16959 FLT3_HUMAN.Y597_E598ins26 Y597_E598ins26 null FLT3_HUMAN 0.176897222713603 3 9 Activating 597 598 insertion 16959 FLT3_HUMAN.Y599_D600insFREYEY Y599_D600insFREYEY null FLT3_HUMAN 0.117931481809069 2 9 Activating 599 600 insertion 16959 FLT3_HUMAN.L610_E611ins21 L610_E611ins21 FLT3_HUMAN/610-943 FLT3_HUMAN 0.235862963618138 4 9 Activating 610 611 insertion 16959 FLT3_HUMAN.Y599_D600ins19 Y599_D600ins19 null FLT3_HUMAN 0.294828704522672 5 9 Activating 599 600 insertion 16959 FLT3_HUMAN.E598_Y599insFYVDFREYE E598_Y599insFYVDFREYE null FLT3_HUMAN 0.0589657409045345 1 9 Activating 598 599 insertion 16959 FLT3_HUMAN.F594_R595ins13 F594_R595ins13 null FLT3_HUMAN 0.117931481809069 2 9 Activating 594 595 insertion 16959 FLT3_HUMAN.E604_F605ins23 E604_F605ins23 null FLT3_HUMAN 0.117931481809069 2 9 Activating 604 605 insertion 16959 FLT3_HUMAN.E598_Y599ins15 E598_Y599ins15 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 598 599 insertion 16959 FLT3_HUMAN.K602_W603ins20 K602_W603ins20 null FLT3_HUMAN 0.235862963618138 4 9 Activating 602 603 insertion 16959 FLT3_HUMAN.F605_P606ins22 F605_P606ins22 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.P606_R607ins24 P606_R607ins24 null FLT3_HUMAN 0.117931481809069 2 9 Activating 606 607 insertion 16959 FLT3_HUMAN.F612_G613ins17 F612_G613ins17 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 612 613 insertion 16959 FLT3_HUMAN.E598_Y599ins12 E598_Y599ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 598 599 insertion 16959 FLT3_HUMAN.D600_L601insFREYEYD D600_L601insFREYEYD null FLT3_HUMAN 1.59207500442243 27 9 Activating 600 601 insertion 16959 FLT3_HUMAN.E611_F612ins31 E611_F612ins31 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 611 612 insertion 16959 FLT3_HUMAN.L601_K602ins28 L601_K602ins28 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.Y591_V592insGSSDNEYFY Y591_V592insGSSDNEYFY null FLT3_HUMAN 0.0589657409045345 1 9 Activating 591 592 insertion 16959 FLT3_HUMAN.D835A D835A FLT3_HUMAN/610-943 FLT3_HUMAN 0.589657409045345 10 9 Activating 835 835 missense 16959 FLT3_HUMAN.F594L F594L null FLT3_HUMAN 0.176897222713603 3 9 Activating 594 594 missense 16959 FLT3_HUMAN.E598_Y599ins25 E598_Y599ins25 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 598 599 insertion 16959 FLT3_HUMAN.F590_D593>PCEN F590_D593>PCEN null FLT3_HUMAN 0.0589657409045345 1 9 Activating 590 593 indel 16959 FLT3_HUMAN.E598_Y599insRGDFREYE E598_Y599insRGDFREYE null FLT3_HUMAN 0.0589657409045345 1 9 Activating 598 599 insertion 16959 FLT3_HUMAN.F605_P606ins12 F605_P606ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.L601_K602ins18 L601_K602ins18 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.L610_E611ins39 L610_E611ins39 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 610 611 insertion 16959 FLT3_HUMAN.E598_Y599ins19 E598_Y599ins19 null FLT3_HUMAN 0.176897222713603 3 9 Activating 598 599 insertion 16959 FLT3_HUMAN.Y597_E598insDVDFREY Y597_E598insDVDFREY null FLT3_HUMAN 0.471725927236276 8 9 Activating 597 598 insertion 16959 FLT3_HUMAN.Q580_V581ins* Q580_V581ins* null FLT3_HUMAN 0.0589657409045345 1 9 Activating 580 581 insertion 16959 FLT3_HUMAN.Y599_D600ins14 Y599_D600ins14 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 599 600 insertion 16959 FLT3_HUMAN.N841K N841K FLT3_HUMAN/610-943 FLT3_HUMAN 0.353794445427207 6 9 Activating 841 841 missense 16959 FLT3_HUMAN.N609_L610ins18 N609_L610ins18 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 609 610 insertion 16959 FLT3_HUMAN.E608_N609ins16 E608_N609ins16 null FLT3_HUMAN 0.235862963618138 4 9 Activating 608 609 insertion 16959 FLT3_HUMAN.I836F I836F FLT3_HUMAN/610-943 FLT3_HUMAN 0.176897222713603 3 9 Activating 836 836 missense 16959 FLT3_HUMAN.D593_F594ins21 D593_F594ins21 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 593 594 insertion 16959 FLT3_HUMAN.Y597_E598ins11 Y597_E598ins11 null FLT3_HUMAN 0.117931481809069 2 9 Activating 597 598 insertion 16959 FLT3_HUMAN.V592_D593ins13 V592_D593ins13 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 592 593 insertion 16959 FLT3_HUMAN.V592_D593ins14 V592_D593ins14 null FLT3_HUMAN 0.117931481809069 2 9 Activating 592 593 insertion 16959 FLT3_HUMAN.W603_E604ins11 W603_E604ins11 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 603 604 insertion 16959 FLT3_HUMAN.D586_N587ins38 D586_N587ins38 null FLT3_HUMAN 0.117931481809069 2 9 Activating 586 587 insertion 16959 FLT3_HUMAN.E604_F605ins15 E604_F605ins15 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 604 605 insertion 16959 FLT3_HUMAN.Y599_D600ins20 Y599_D600ins20 null FLT3_HUMAN 0.117931481809069 2 9 Activating 599 600 insertion 16959 FLT3_HUMAN.D600_L601ins16 D600_L601ins16 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 600 601 insertion 16959 FLT3_HUMAN.I836V I836V FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 836 836 missense 16959 FLT3_HUMAN.E608_N609ins12 E608_N609ins12 null FLT3_HUMAN 0.117931481809069 2 9 Activating 608 609 insertion 16959 FLT3_HUMAN.E598_Y599ins16 E598_Y599ins16 null FLT3_HUMAN 0.117931481809069 2 9 Activating 598 599 insertion 16959 FLT3_HUMAN.L610_E611ins20 L610_E611ins20 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 610 611 insertion 16959 FLT3_HUMAN.E608_N609ins31 E608_N609ins31 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 608 609 insertion 16959 FLT3_HUMAN.Y599_D600ins15 Y599_D600ins15 null FLT3_HUMAN 0.176897222713603 3 9 Activating 599 600 insertion 16959 FLT3_HUMAN.K614_V615ins36 K614_V615ins36 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 614 615 insertion 16959 FLT3_HUMAN.E611_F612ins10 E611_F612ins10 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 611 612 insertion 16959 FLT3_HUMAN.F612_G613ins24 F612_G613ins24 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 612 613 insertion 16959 FLT3_HUMAN.E608_N609ins23 E608_N609ins23 null FLT3_HUMAN 0.117931481809069 2 9 Activating 608 609 insertion 16959 FLT3_HUMAN.L610_E611ins19 L610_E611ins19 FLT3_HUMAN/610-943 FLT3_HUMAN 0.176897222713603 3 9 Activating 610 611 insertion 16959 FLT3_HUMAN.R607_E608ins14 R607_E608ins14 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 607 608 insertion 16959 FLT3_HUMAN.R607_E608ins27 R607_E608ins27 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 607 608 insertion 16959 FLT3_HUMAN.N587_E588ins30 N587_E588ins30 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 587 588 insertion 16959 FLT3_HUMAN.K602_W603ins23 K602_W603ins23 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 602 603 insertion 16959 FLT3_HUMAN.L601_K602ins21 L601_K602ins21 null FLT3_HUMAN 0.176897222713603 3 9 Activating 601 602 insertion 16959 FLT3_HUMAN.D835I D835I FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 835 835 missense 16959 FLT3_HUMAN.W603_E604insYEYDLKW W603_E604insYEYDLKW null FLT3_HUMAN 0.0589657409045345 1 9 Activating 603 604 insertion 16959 FLT3_HUMAN.V592_D593ins12 V592_D593ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 592 593 insertion 16959 FLT3_HUMAN.E596_Y597ins25 E596_Y597ins25 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 596 597 insertion 16959 FLT3_HUMAN.W603_E604ins16 W603_E604ins16 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 603 604 insertion 16959 FLT3_HUMAN.F612_G613ins15 F612_G613ins15 FLT3_HUMAN/610-943 FLT3_HUMAN 0.176897222713603 3 9 Activating 612 613 insertion 16959 FLT3_HUMAN.Y591D Y591D null FLT3_HUMAN 0.0589657409045345 1 9 Activating 591 591 missense 16959 FLT3_HUMAN.R595_E596ins12 R595_E596ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 595 596 insertion 16959 FLT3_HUMAN.Y599_D600ins10 Y599_D600ins10 null FLT3_HUMAN 0.117931481809069 2 9 Activating 599 600 insertion 16959 FLT3_HUMAN.Y597_E598ins17 Y597_E598ins17 null FLT3_HUMAN 0.176897222713603 3 9 Activating 597 598 insertion 16959 FLT3_HUMAN.E598_Y599ins17 E598_Y599ins17 null FLT3_HUMAN 0.235862963618138 4 9 Activating 598 599 insertion 16959 FLT3_HUMAN.F590_F594>L F590_F594>L null FLT3_HUMAN 0.0589657409045345 1 9 Activating 590 594 indel 16959 FLT3_HUMAN.L610_E611ins64 L610_E611ins64 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 610 611 insertion 16959 FLT3_HUMAN.E608_N609ins11 E608_N609ins11 null FLT3_HUMAN 0.117931481809069 2 9 Activating 608 609 insertion 16959 FLT3_HUMAN.D835N D835N FLT3_HUMAN/610-943 FLT3_HUMAN 0.53069166814081 9 9 Activating 835 835 missense 16959 FLT3_HUMAN.N609_L610ins15 N609_L610ins15 null FLT3_HUMAN 0.117931481809069 2 9 Activating 609 610 insertion 16959 FLT3_HUMAN.W603_E604insDEYDLKW W603_E604insDEYDLKW null FLT3_HUMAN 0.0589657409045345 1 9 Activating 603 604 insertion 16959 FLT3_HUMAN.L601_K602ins24 L601_K602ins24 null FLT3_HUMAN 0.176897222713603 3 9 Activating 601 602 insertion 16959 FLT3_HUMAN.F590_Y591ins10 F590_Y591ins10 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 590 591 insertion 16959 FLT3_HUMAN.Y599_D600ins26 Y599_D600ins26 null FLT3_HUMAN 0.117931481809069 2 9 Activating 599 600 insertion 16959 FLT3_HUMAN.V592_D593insG V592_D593insG null FLT3_HUMAN 0.0589657409045345 1 9 Activating 592 593 insertion 16959 FLT3_HUMAN.E611_F612ins13 E611_F612ins13 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 611 612 insertion 16959 FLT3_HUMAN.P606_R607insYDLKWEFP P606_R607insYDLKWEFP null FLT3_HUMAN 0.294828704522672 5 9 Activating 606 607 insertion 16959 FLT3_HUMAN.E611_F612ins25 E611_F612ins25 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 611 612 insertion 16959 FLT3_HUMAN.E596_Y597ins14 E596_Y597ins14 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 596 597 insertion 16959 FLT3_HUMAN.P606_R607ins16 P606_R607ins16 null FLT3_HUMAN 0.117931481809069 2 9 Activating 606 607 insertion 16959 FLT3_HUMAN.Y591_V592ins15 Y591_V592ins15 null FLT3_HUMAN 0.117931481809069 2 9 Activating 591 592 insertion 16959 FLT3_HUMAN.G613_K614ins35 G613_K614ins35 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 613 614 insertion 16959 FLT3_HUMAN.E604_F605ins12 E604_F605ins12 null FLT3_HUMAN 0.235862963618138 4 9 Activating 604 605 insertion 16959 FLT3_HUMAN.L610_E611ins13 L610_E611ins13 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 610 611 insertion 16959 FLT3_HUMAN.L601_K602insIREYEYDL L601_K602insIREYEYDL null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.Y591_V592ins23 Y591_V592ins23 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 591 592 insertion 16959 FLT3_HUMAN.D593_F594insWGYFYVD D593_F594insWGYFYVD null FLT3_HUMAN 0.0589657409045345 1 9 Activating 593 594 insertion 16959 FLT3_HUMAN.F590_E596>LG F590_E596>LG null FLT3_HUMAN 0.0589657409045345 1 9 Activating 590 596 indel 16959 FLT3_HUMAN.G613_K614ins16 G613_K614ins16 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 613 614 insertion 16959 FLT3_HUMAN.F590_Y591insFQRI* F590_Y591insFQRI* null FLT3_HUMAN 0.0589657409045345 1 9 Activating 590 591 insertion 16959 FLT3_HUMAN.F590_Y591ins* F590_Y591ins* null FLT3_HUMAN 0.0589657409045345 1 9 Activating 590 591 insertion 16959 FLT3_HUMAN.D593_F594ins19 D593_F594ins19 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 593 594 insertion 16959 FLT3_HUMAN.E596_Y597insRE E596_Y597insRE null FLT3_HUMAN 0.0589657409045345 1 9 Activating 596 597 insertion 16959 FLT3_HUMAN.W603_E604ins21 W603_E604ins21 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 603 604 insertion 16959 FLT3_HUMAN.E596_Y597insFDFRE E596_Y597insFDFRE null FLT3_HUMAN 0.0589657409045345 1 9 Activating 596 597 insertion 16959 FLT3_HUMAN.F594_R595insSPYF F594_R595insSPYF null FLT3_HUMAN 0.0589657409045345 1 9 Activating 594 595 insertion 16959 FLT3_HUMAN.Y597_E598ins13 Y597_E598ins13 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 597 598 insertion 16959 FLT3_HUMAN.K614_V615ins35 K614_V615ins35 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 614 615 insertion 16959 FLT3_HUMAN.F612_G613ins12 F612_G613ins12 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 612 613 insertion 16959 FLT3_HUMAN.P606_R607ins14 P606_R607ins14 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 606 607 insertion 16959 FLT3_HUMAN.L601_K602insREYEYDL L601_K602insREYEYDL null FLT3_HUMAN 0.707588890854414 12 9 Activating 601 602 insertion 16959 FLT3_HUMAN.W603_E604ins15 W603_E604ins15 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 603 604 insertion 16959 FLT3_HUMAN.D593_F594insNEYFYVD D593_F594insNEYFYVD null FLT3_HUMAN 0.0589657409045345 1 9 Activating 593 594 insertion 16959 FLT3_HUMAN.R607_E608ins30 R607_E608ins30 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 607 608 insertion 16959 FLT3_HUMAN.F594_R595ins15 F594_R595ins15 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 594 595 insertion 16959 FLT3_HUMAN.E598_Y599insDYVDFREYE E598_Y599insDYVDFREYE null FLT3_HUMAN 0.0589657409045345 1 9 Activating 598 599 insertion 16959 FLT3_HUMAN.F605_P606ins28 F605_P606ins28 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.D593_F594insD D593_F594insD null FLT3_HUMAN 0.0589657409045345 1 9 Activating 593 594 insertion 16959 FLT3_HUMAN.L601_K602insPGGYEYDL L601_K602insPGGYEYDL null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.D600_L601ins23 D600_L601ins23 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 600 601 insertion 16959 FLT3_HUMAN.D600_L601ins12 D600_L601ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 600 601 insertion 16959 FLT3_HUMAN.R595_E596ins16 R595_E596ins16 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 595 596 insertion 16959 FLT3_HUMAN.Q580_V581ins12 Q580_V581ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 580 581 insertion 16959 FLT3_HUMAN.F612_G613ins34 F612_G613ins34 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 612 613 insertion 16959 FLT3_HUMAN.R595_E596insDFYVDFR R595_E596insDFYVDFR null FLT3_HUMAN 0.176897222713603 3 9 Activating 595 596 insertion 16959 FLT3_HUMAN.G613_K614ins23 G613_K614ins23 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 613 614 insertion 16959 FLT3_HUMAN.L601_K602ins20 L601_K602ins20 null FLT3_HUMAN 0.117931481809069 2 9 Activating 601 602 insertion 16959 FLT3_HUMAN.Y597_E598insGDFREY Y597_E598insGDFREY null FLT3_HUMAN 0.117931481809069 2 9 Activating 597 598 insertion 16959 FLT3_HUMAN.E608_N609insWEFPRE E608_N609insWEFPRE null FLT3_HUMAN 0.0589657409045345 1 9 Activating 608 609 insertion 16959 FLT3_HUMAN.Y599_D600ins12 Y599_D600ins12 null FLT3_HUMAN 0.235862963618138 4 9 Activating 599 600 insertion 16959 FLT3_HUMAN.W603_E604insGEYEYDLKW W603_E604insGEYEYDLKW null FLT3_HUMAN 0.0589657409045345 1 9 Activating 603 604 insertion 16959 FLT3_HUMAN.E604_F605ins10 E604_F605ins10 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 604 605 insertion 16959 FLT3_HUMAN.N609_L610ins11 N609_L610ins11 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 609 610 insertion 16959 FLT3_HUMAN.R595_E596ins14 R595_E596ins14 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 595 596 insertion 16959 FLT3_HUMAN.Y599_D600ins23 Y599_D600ins23 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 599 600 insertion 16959 FLT3_HUMAN.D593_F594insTDNEYFYVD D593_F594insTDNEYFYVD null FLT3_HUMAN 0.117931481809069 2 9 Activating 593 594 insertion 16959 FLT3_HUMAN.L610_E611ins25 L610_E611ins25 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 610 611 insertion 16959 FLT3_HUMAN.W603_E604ins14 W603_E604ins14 null FLT3_HUMAN 0.176897222713603 3 9 Activating 603 604 insertion 16959 FLT3_HUMAN.E598_Y599insE E598_Y599insE null FLT3_HUMAN 0.0589657409045345 1 9 Activating 598 599 insertion 16959 FLT3_HUMAN.E604_F605insYEYDLKWE E604_F605insYEYDLKWE null FLT3_HUMAN 0.235862963618138 4 9 Activating 604 605 insertion 16959 FLT3_HUMAN.D600_L601insVDFREYEYD D600_L601insVDFREYEYD null FLT3_HUMAN 0.117931481809069 2 9 Activating 600 601 insertion 16959 FLT3_HUMAN.F605_P606insHEYDLKWEF F605_P606insHEYDLKWEF null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.D835F D835F FLT3_HUMAN/610-943 FLT3_HUMAN 0.176897222713603 3 9 Activating 835 835 missense 16959 FLT3_HUMAN.F605_P606ins11 F605_P606ins11 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.P606_R607ins10 P606_R607ins10 null FLT3_HUMAN 0.117931481809069 2 9 Activating 606 607 insertion 16959 FLT3_HUMAN.E608_N609ins13 E608_N609ins13 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 608 609 insertion 16959 FLT3_HUMAN.E611_F612ins15 E611_F612ins15 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 611 612 insertion 16959 FLT3_HUMAN.Y597_E598insDFYVDFREY Y597_E598insDFYVDFREY null FLT3_HUMAN 0.117931481809069 2 9 Activating 597 598 insertion 16959 FLT3_HUMAN.P606_R607ins15 P606_R607ins15 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 606 607 insertion 16959 FLT3_HUMAN.P606_R607ins20 P606_R607ins20 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 606 607 insertion 16959 FLT3_HUMAN.K602_W603insCREYEYDLK K602_W603insCREYEYDLK null FLT3_HUMAN 0.0589657409045345 1 9 Activating 602 603 insertion 16959 FLT3_HUMAN.F612_G613ins35 F612_G613ins35 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 612 613 insertion 16959 FLT3_HUMAN.L601_K602ins13 L601_K602ins13 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.D835Y D835Y FLT3_HUMAN/610-943 FLT3_HUMAN 24.4707824753818 415 9 Activating 835 835 missense 16959 FLT3_HUMAN.Y591C Y591C null FLT3_HUMAN 0.0589657409045345 1 9 Activating 591 591 missense 16959 FLT3_HUMAN.D600_L601insGDFREYEYD D600_L601insGDFREYEYD null FLT3_HUMAN 0.0589657409045345 1 9 Activating 600 601 insertion 16959 FLT3_HUMAN.K602_W603ins19 K602_W603ins19 null FLT3_HUMAN 0.117931481809069 2 9 Activating 602 603 insertion 16959 FLT3_HUMAN.F605_P606ins13 F605_P606ins13 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.I836D I836D FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 836 836 missense 16959 FLT3_HUMAN.L601_K602insEYEYDL L601_K602insEYEYDL null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.L610_E611ins17 L610_E611ins17 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 610 611 insertion 16959 FLT3_HUMAN.Y597_E598insSPNDFREY Y597_E598insSPNDFREY null FLT3_HUMAN 0.117931481809069 2 9 Activating 597 598 insertion 16959 FLT3_HUMAN.I836H I836H FLT3_HUMAN/610-943 FLT3_HUMAN 0.412760186331741 7 9 Activating 836 836 missense 16959 FLT3_HUMAN.L601_K602ins15 L601_K602ins15 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.F590_Y591insDNEYF F590_Y591insDNEYF null FLT3_HUMAN 0.0589657409045345 1 9 Activating 590 591 insertion 16959 FLT3_HUMAN.L610_E611ins11 L610_E611ins11 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 610 611 insertion 16959 FLT3_HUMAN.L601_K602ins19 L601_K602ins19 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.E596_Y597ins22 E596_Y597ins22 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 596 597 insertion 16959 FLT3_HUMAN.L601_K602ins12 L601_K602ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.R595_E596ins17 R595_E596ins17 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 595 596 insertion 16959 FLT3_HUMAN.E598_Y599ins21 E598_Y599ins21 null FLT3_HUMAN 0.294828704522672 5 9 Activating 598 599 insertion 16959 FLT3_HUMAN.D600_L601ins26 D600_L601ins26 null FLT3_HUMAN 0.117931481809069 2 9 Activating 600 601 insertion 16959 FLT3_HUMAN.F612_G613ins28 F612_G613ins28 FLT3_HUMAN/610-943 FLT3_HUMAN 0.176897222713603 3 9 Activating 612 613 insertion 16959 FLT3_HUMAN.F612_G613ins21 F612_G613ins21 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 612 613 insertion 16959 FLT3_HUMAN.R595_E596ins13 R595_E596ins13 null FLT3_HUMAN 0.117931481809069 2 9 Activating 595 596 insertion 16959 FLT3_HUMAN.E611_F612ins20 E611_F612ins20 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 611 612 insertion 16959 FLT3_HUMAN.P606_R607ins21 P606_R607ins21 null FLT3_HUMAN 0.117931481809069 2 9 Activating 606 607 insertion 16959 FLT3_HUMAN.E596_Y597insEYFYVDFRE E596_Y597insEYFYVDFRE null FLT3_HUMAN 0.0589657409045345 1 9 Activating 596 597 insertion 16959 FLT3_HUMAN.N609_L610ins19 N609_L610ins19 null FLT3_HUMAN 0.117931481809069 2 9 Activating 609 610 insertion 16959 FLT3_HUMAN.E598_Y599insFDFREYE E598_Y599insFDFREYE null FLT3_HUMAN 0.0589657409045345 1 9 Activating 598 599 insertion 16959 FLT3_HUMAN.E596_Y597ins11 E596_Y597ins11 null FLT3_HUMAN 0.176897222713603 3 9 Activating 596 597 insertion 16959 FLT3_HUMAN.F594_R595ins14 F594_R595ins14 null FLT3_HUMAN 0.117931481809069 2 9 Activating 594 595 insertion 16959 FLT3_HUMAN.D600_L601ins17 D600_L601ins17 null FLT3_HUMAN 0.235862963618138 4 9 Activating 600 601 insertion 16959 FLT3_HUMAN.E596_Y597insYVDFRE E596_Y597insYVDFRE null FLT3_HUMAN 0.0589657409045345 1 9 Activating 596 597 insertion 16959 FLT3_HUMAN.E598_Y599ins22 E598_Y599ins22 null FLT3_HUMAN 0.117931481809069 2 9 Activating 598 599 insertion 16959 FLT3_HUMAN.I836L I836L FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 836 836 missense 16959 FLT3_HUMAN.F612_G613insD F612_G613insD FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 612 613 insertion 16959 FLT3_HUMAN.P606_R607ins18 P606_R607ins18 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 606 607 insertion 16959 FLT3_HUMAN.F605_P606insGEYDLKWEF F605_P606insGEYDLKWEF null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.Y597_E598insDDFREY Y597_E598insDDFREY null FLT3_HUMAN 0.0589657409045345 1 9 Activating 597 598 insertion 16959 FLT3_HUMAN.L601_K602insDFREYEYDL L601_K602insDFREYEYDL null FLT3_HUMAN 0.117931481809069 2 9 Activating 601 602 insertion 16959 FLT3_HUMAN.D600_L601ins22 D600_L601ins22 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 600 601 insertion 16959 FLT3_HUMAN.D593_F594insLDNEYFYVD D593_F594insLDNEYFYVD null FLT3_HUMAN 0.117931481809069 2 9 Activating 593 594 insertion 16959 FLT3_HUMAN.E604_F605ins21 E604_F605ins21 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 604 605 insertion 16959 FLT3_HUMAN.F594_R595ins21 F594_R595ins21 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 594 595 insertion 16959 FLT3_HUMAN.E608_N609ins25 E608_N609ins25 null FLT3_HUMAN 0.117931481809069 2 9 Activating 608 609 insertion 16959 FLT3_HUMAN.L601_K602ins29 L601_K602ins29 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.L610_E611ins16 L610_E611ins16 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 610 611 insertion 16959 FLT3_HUMAN.K614_V615ins30 K614_V615ins30 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 614 615 insertion 16959 FLT3_HUMAN.D593_F594ins16 D593_F594ins16 null FLT3_HUMAN 0.176897222713603 3 9 Activating 593 594 insertion 16959 FLT3_HUMAN.D600_L601insIIFIFSEI D600_L601insIIFIFSEI null FLT3_HUMAN 0.0589657409045345 1 9 Activating 600 601 insertion 16959 FLT3_HUMAN.E604_F605ins24 E604_F605ins24 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 604 605 insertion 16959 FLT3_HUMAN.R595_E596ins10 R595_E596ins10 null FLT3_HUMAN 0.235862963618138 4 9 Activating 595 596 insertion 16959 FLT3_HUMAN.D835V D835V FLT3_HUMAN/610-943 FLT3_HUMAN 5.24795094050357 89 9 Activating 835 835 missense 16959 FLT3_HUMAN.K602_W603ins14 K602_W603ins14 null FLT3_HUMAN 0.117931481809069 2 9 Activating 602 603 insertion 16959 FLT3_HUMAN.Y599_D600insDFREYEY Y599_D600insDFREYEY null FLT3_HUMAN 0.0589657409045345 1 9 Activating 599 600 insertion 16959 FLT3_HUMAN.F612_G613ins18 F612_G613ins18 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 612 613 insertion 16959 FLT3_HUMAN.L610_E611ins32 L610_E611ins32 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 610 611 insertion 16959 FLT3_HUMAN.E596_Y597ins16 E596_Y597ins16 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 596 597 insertion 16959 FLT3_HUMAN.F594_R595ins10 F594_R595ins10 null FLT3_HUMAN 0.235862963618138 4 9 Activating 594 595 insertion 16959 FLT3_HUMAN.K614_V615ins15 K614_V615ins15 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 614 615 insertion 16959 FLT3_HUMAN.N609_L610ins27 N609_L610ins27 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 609 610 insertion 16959 FLT3_HUMAN.G613_K614ins15 G613_K614ins15 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 613 614 insertion 16959 FLT3_HUMAN.W603_E604ins12 W603_E604ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 603 604 insertion 16959 FLT3_HUMAN.E596_Y597ins15 E596_Y597ins15 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 596 597 insertion 16959 FLT3_HUMAN.D593_F594insLDEYFYVD D593_F594insLDEYFYVD null FLT3_HUMAN 0.117931481809069 2 9 Activating 593 594 insertion 16959 FLT3_HUMAN.E611_F612ins34 E611_F612ins34 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 611 612 insertion 16959 FLT3_HUMAN.R595_E596ins26 R595_E596ins26 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 595 596 insertion 16959 FLT3_HUMAN.F612_G613ins16 F612_G613ins16 FLT3_HUMAN/610-943 FLT3_HUMAN 0.176897222713603 3 9 Activating 612 613 insertion 16959 FLT3_HUMAN.E596_Y597insRTDFRE E596_Y597insRTDFRE null FLT3_HUMAN 0.0589657409045345 1 9 Activating 596 597 insertion 16959 FLT3_HUMAN.D600_L601insDFREYEYD D600_L601insDFREYEYD null FLT3_HUMAN 0.0589657409045345 1 9 Activating 600 601 insertion 16959 FLT3_HUMAN.D839G D839G FLT3_HUMAN/610-943 FLT3_HUMAN 1.17931481809069 20 9 Activating 839 839 missense 16959 FLT3_HUMAN.F612_G613ins20 F612_G613ins20 FLT3_HUMAN/610-943 FLT3_HUMAN 0.471725927236276 8 9 Activating 612 613 insertion 16959 FLT3_HUMAN.E608_N609insI* E608_N609insI* null FLT3_HUMAN 0.0589657409045345 1 9 Activating 608 609 insertion 16959 FLT3_HUMAN.D600_L601ins14 D600_L601ins14 null FLT3_HUMAN 0.176897222713603 3 9 Activating 600 601 insertion 16959 FLT3_HUMAN.D600_L601insRGYEYD D600_L601insRGYEYD null FLT3_HUMAN 0.0589657409045345 1 9 Activating 600 601 insertion 16959 FLT3_HUMAN.Y599_D600insYVDFREYEY Y599_D600insYVDFREYEY null FLT3_HUMAN 0.176897222713603 3 9 Activating 599 600 insertion 16959 FLT3_HUMAN.D835E D835E FLT3_HUMAN/610-943 FLT3_HUMAN 4.36346482693555 74 9 Activating 835 835 missense 16959 FLT3_HUMAN.V592A V592A null FLT3_HUMAN 0.353794445427207 6 9 Activating 592 592 missense 16959 FLT3_HUMAN.L601_K602ins33 L601_K602ins33 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.F590_Y591insHT F590_Y591insHT null FLT3_HUMAN 0.0589657409045345 1 9 Activating 590 591 insertion 16959 FLT3_HUMAN.E611_F612ins23 E611_F612ins23 FLT3_HUMAN/610-943 FLT3_HUMAN 0.176897222713603 3 9 Activating 611 612 insertion 16959 FLT3_HUMAN.E598_Y599ins10 E598_Y599ins10 null FLT3_HUMAN 0.176897222713603 3 9 Activating 598 599 insertion 16959 FLT3_HUMAN.E598_Y599ins20 E598_Y599ins20 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 598 599 insertion 16959 FLT3_HUMAN.E598_Y599insFREYE E598_Y599insFREYE null FLT3_HUMAN 0.176897222713603 3 9 Activating 598 599 insertion 16959 FLT3_HUMAN.E596_Y597insG E596_Y597insG null FLT3_HUMAN 0.0589657409045345 1 9 Activating 596 597 insertion 16959 FLT3_HUMAN.E598_Y599insDFREYE E598_Y599insDFREYE null FLT3_HUMAN 0.0589657409045345 1 9 Activating 598 599 insertion 16959 FLT3_HUMAN.Y599_D600insR* Y599_D600insR* null FLT3_HUMAN 0.0589657409045345 1 9 Activating 599 600 insertion 16959 FLT3_HUMAN.G613_K614ins22 G613_K614ins22 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 613 614 insertion 16959 FLT3_HUMAN.F605_P606insDLKWEF F605_P606insDLKWEF null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.F612_G613ins22 F612_G613ins22 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 612 613 insertion 16959 FLT3_HUMAN.D600_L601ins20 D600_L601ins20 null FLT3_HUMAN 0.117931481809069 2 9 Activating 600 601 insertion 16959 FLT3_HUMAN.W603_E604ins13 W603_E604ins13 null FLT3_HUMAN 0.176897222713603 3 9 Activating 603 604 insertion 16959 FLT3_HUMAN.E598_Y599ins23 E598_Y599ins23 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 598 599 insertion 16959 FLT3_HUMAN.K602_W603ins22 K602_W603ins22 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 602 603 insertion 16959 FLT3_HUMAN.N609_L610ins25 N609_L610ins25 null FLT3_HUMAN 0.117931481809069 2 9 Activating 609 610 insertion 16959 FLT3_HUMAN.F594_R595ins11 F594_R595ins11 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 594 595 insertion 16959 FLT3_HUMAN.L610_E611ins26 L610_E611ins26 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 610 611 insertion 16959 FLT3_HUMAN.K602_W603ins12 K602_W603ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 602 603 insertion 16959 FLT3_HUMAN.P606_R607ins29 P606_R607ins29 null FLT3_HUMAN 0.176897222713603 3 9 Activating 606 607 insertion 16959 FLT3_HUMAN.F612_G613ins30 F612_G613ins30 FLT3_HUMAN/610-943 FLT3_HUMAN 0.176897222713603 3 9 Activating 612 613 insertion 16959 FLT3_HUMAN.T582_G583insA T582_G583insA null FLT3_HUMAN 0.0589657409045345 1 9 Activating 582 583 insertion 16959 FLT3_HUMAN.L601_K602insQRI* L601_K602insQRI* null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.E608_N609ins29 E608_N609ins29 null FLT3_HUMAN 0.117931481809069 2 9 Activating 608 609 insertion 16959 FLT3_HUMAN.F612_G613ins23 F612_G613ins23 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 612 613 insertion 16959 FLT3_HUMAN.F594_R595ins12 F594_R595ins12 null FLT3_HUMAN 0.294828704522672 5 9 Activating 594 595 insertion 16959 FLT3_HUMAN.F605_P606ins20 F605_P606ins20 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.Y597_E598insGLGVDFREY Y597_E598insGLGVDFREY null FLT3_HUMAN 0.0589657409045345 1 9 Activating 597 598 insertion 16959 FLT3_HUMAN.I836S I836S FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 836 836 missense 16959 FLT3_HUMAN.R607_E608ins26 R607_E608ins26 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 607 608 insertion 16959 FLT3_HUMAN.G613_K614ins33 G613_K614ins33 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 613 614 insertion 16959 FLT3_HUMAN.K602_W603insEYEYDLK K602_W603insEYEYDLK null FLT3_HUMAN 0.117931481809069 2 9 Activating 602 603 insertion 16959 FLT3_HUMAN.D586_N587ins15 D586_N587ins15 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 586 587 insertion 16959 FLT3_HUMAN.R595_E596insDQNLYVDFR R595_E596insDQNLYVDFR null FLT3_HUMAN 0.0589657409045345 1 9 Activating 595 596 insertion 16959 FLT3_HUMAN.D593_F594ins11 D593_F594ins11 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 593 594 insertion 16959 FLT3_HUMAN.E611_F612ins22 E611_F612ins22 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 611 612 insertion 16959 FLT3_HUMAN.F605_P606ins10 F605_P606ins10 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.T582_G583ins14 T582_G583ins14 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 582 583 insertion 16959 FLT3_HUMAN.P606_R607ins12 P606_R607ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 606 607 insertion 16959 FLT3_HUMAN.D600_L601ins28 D600_L601ins28 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 600 601 insertion 16959 FLT3_HUMAN.E596_Y597ins12 E596_Y597ins12 null FLT3_HUMAN 0.235862963618138 4 9 Activating 596 597 insertion 16959 FLT3_HUMAN.F605_P606insEYDLKWEF F605_P606insEYDLKWEF null FLT3_HUMAN 0.0589657409045345 1 9 Activating 605 606 insertion 16959 FLT3_HUMAN.E611_F612ins38 E611_F612ins38 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 611 612 insertion 16959 FLT3_HUMAN.L601_K602ins10 L601_K602ins10 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.R595_E596ins24 R595_E596ins24 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 595 596 insertion 16959 FLT3_HUMAN.F612_G613ins19 F612_G613ins19 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 612 613 insertion 16959 FLT3_HUMAN.P606_R607ins13 P606_R607ins13 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 606 607 insertion 16959 FLT3_HUMAN.D835H D835H FLT3_HUMAN/610-943 FLT3_HUMAN 5.3069166814081 90 9 Activating 835 835 missense 16959 FLT3_HUMAN.Y597_E598ins27 Y597_E598ins27 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 597 598 insertion 16959 FLT3_HUMAN.V579A V579A null FLT3_HUMAN 0.0589657409045345 1 9 Activating 579 579 missense 16959 FLT3_HUMAN.T582_G583insWYR* T582_G583insWYR* null FLT3_HUMAN 0.0589657409045345 1 9 Activating 582 583 insertion 16959 FLT3_HUMAN.L601_K602insNGEYEYDL L601_K602insNGEYEYDL null FLT3_HUMAN 0.117931481809069 2 9 Activating 601 602 insertion 16959 FLT3_HUMAN.G613_K614ins28 G613_K614ins28 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 613 614 insertion 16959 FLT3_HUMAN.Y597_E598ins15 Y597_E598ins15 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 597 598 insertion 16959 FLT3_HUMAN.Y597_E598ins12 Y597_E598ins12 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 597 598 insertion 16959 FLT3_HUMAN.K663Q K663Q FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 663 663 missense 16959 FLT3_HUMAN.E604_F605ins22 E604_F605ins22 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 604 605 insertion 16959 FLT3_HUMAN.R595_E596insNEYFYVDFR R595_E596insNEYFYVDFR null FLT3_HUMAN 0.0589657409045345 1 9 Activating 595 596 insertion 16959 FLT3_HUMAN.F605_P606ins23 F605_P606ins23 null FLT3_HUMAN 0.117931481809069 2 9 Activating 605 606 insertion 16959 FLT3_HUMAN.Y599_D600ins32 Y599_D600ins32 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 599 600 insertion 16959 FLT3_HUMAN.F612_G613ins26 F612_G613ins26 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 612 613 insertion 16959 FLT3_HUMAN.K602_W603insYEYDLK K602_W603insYEYDLK null FLT3_HUMAN 0.353794445427207 6 9 Activating 602 603 insertion 16959 FLT3_HUMAN.D600_L601ins21 D600_L601ins21 null FLT3_HUMAN 0.117931481809069 2 9 Activating 600 601 insertion 16959 FLT3_HUMAN.K602_W603ins17 K602_W603ins17 null FLT3_HUMAN 0.117931481809069 2 9 Activating 602 603 insertion 16959 FLT3_HUMAN.R607_E608insDLKWEFPR R607_E608insDLKWEFPR null FLT3_HUMAN 0.0589657409045345 1 9 Activating 607 608 insertion 16959 FLT3_HUMAN.G613_K614ins17 G613_K614ins17 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 613 614 insertion 16959 FLT3_HUMAN.L610_E611ins37 L610_E611ins37 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 610 611 insertion 16959 FLT3_HUMAN.N609_L610ins10 N609_L610ins10 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 609 610 insertion 16959 FLT3_HUMAN.E608_N609ins19 E608_N609ins19 null FLT3_HUMAN 0.117931481809069 2 9 Activating 608 609 insertion 16959 FLT3_HUMAN.W603_E604ins22 W603_E604ins22 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 603 604 insertion 16959 FLT3_HUMAN.P606_R607ins17 P606_R607ins17 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 606 607 insertion 16959 FLT3_HUMAN.V592_D593ins20 V592_D593ins20 null FLT3_HUMAN 0.235862963618138 4 9 Activating 592 593 insertion 16959 FLT3_HUMAN.L601_K602insGLNEYDL L601_K602insGLNEYDL null FLT3_HUMAN 0.0589657409045345 1 9 Activating 601 602 insertion 16959 FLT3_HUMAN.L601_K602ins27 L601_K602ins27 null FLT3_HUMAN 0.235862963618138 4 9 Activating 601 602 insertion 16959 FLT3_HUMAN.F612_G613ins25 F612_G613ins25 FLT3_HUMAN/610-943 FLT3_HUMAN 0.117931481809069 2 9 Activating 612 613 insertion 16959 FLT3_HUMAN.D593_F594ins14 D593_F594ins14 null FLT3_HUMAN 0.117931481809069 2 9 Activating 593 594 insertion 16959 FLT3_HUMAN.E604_F605insYDLKWE E604_F605insYDLKWE null FLT3_HUMAN 0.176897222713603 3 9 Activating 604 605 insertion 16959 FLT3_HUMAN.N676K N676K FLT3_HUMAN/610-943 FLT3_HUMAN 2.35862963618138 40 9 Activating 676 676 missense 16959 FLT3_HUMAN.Y591_V592ins14 Y591_V592ins14 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 591 592 insertion 16959 FLT3_HUMAN.P606_R607ins26 P606_R607ins26 null FLT3_HUMAN 0.117931481809069 2 9 Activating 606 607 insertion 16959 FLT3_HUMAN.K602_W603insFREYEYDLK K602_W603insFREYEYDLK null FLT3_HUMAN 0.0589657409045345 1 9 Activating 602 603 insertion 16959 FLT3_HUMAN.I836M I836M FLT3_HUMAN/610-943 FLT3_HUMAN 0.412760186331741 7 9 Activating 836 836 missense 16959 FLT3_HUMAN.Y599_D600ins18 Y599_D600ins18 null FLT3_HUMAN 0.0589657409045345 1 9 Activating 599 600 insertion 16959 NEK8_HUMAN.A197P A197P NEK8_HUMAN/4-258 NEK8_HUMAN 4.76190476190476 1 7 Activating 197 197 missense 210 TTK_HUMAN.D697Y D697Y TTK_HUMAN/525-791 TTK_HUMAN 3.64963503649635 1 7 Activating 697 697 missense 274 EGFR_HUMAN.T751_I759>N T751_I759>N EGFR_HUMAN/712-968 EGFR_HUMAN 0.644745325596389 17 10 Activating 751 759 indel 26367 EGFR_HUMAN.E746_T751>V E746_T751>V EGFR_HUMAN/712-968 EGFR_HUMAN 0.455114347479804 12 10 Activating 746 751 indel 26367 EGFR_HUMAN.L747S L747S EGFR_HUMAN/712-968 EGFR_HUMAN 0.568892934349755 15 10 Activating 747 747 missense 26367 EGFR_HUMAN.T751_I759>S T751_I759>S EGFR_HUMAN/712-968 EGFR_HUMAN 0.113778586869951 3 10 Activating 751 759 indel 26367 EGFR_HUMAN.V689M V689M null EGFR_HUMAN 0.037926195623317 1 10 Activating 689 689 missense 26367 EGFR_HUMAN.K846R K846R EGFR_HUMAN/712-968 EGFR_HUMAN 0.037926195623317 1 10 Activating 846 846 missense 26367 EGFR_HUMAN.A839T A839T EGFR_HUMAN/712-968 EGFR_HUMAN 0.189630978116585 5 10 Activating 839 839 missense 26367 EGFR_HUMAN.L747_T751>P L747_T751>P EGFR_HUMAN/712-968 EGFR_HUMAN 1.74460499867258 46 10 Activating 747 751 indel 26367 EGFR_HUMAN.S768I S768I EGFR_HUMAN/712-968 EGFR_HUMAN 9.32984412333599 246 10 Activating 768 768 missense 26367 EGFR_HUMAN.L814P L814P EGFR_HUMAN/712-968 EGFR_HUMAN 0.113778586869951 3 10 Activating 814 814 missense 26367 EGFR_HUMAN.G719S G719S EGFR_HUMAN/712-968 EGFR_HUMAN 5.27174119164107 139 10 Activating 719 719 missense 26367 EGFR_HUMAN.L838P L838P EGFR_HUMAN/712-968 EGFR_HUMAN 0.151704782493268 4 10 Activating 838 838 missense 26367 EGFR_HUMAN.T790M T790M EGFR_HUMAN/712-968 EGFR_HUMAN 46.7629992035499 1233 10 Activating 790 790 missense 26367 EGFR_HUMAN.R776H R776H EGFR_HUMAN/712-968 EGFR_HUMAN 0.682671521219706 18 10 Activating 776 776 missense 26367 EGFR_HUMAN.E709V E709V null EGFR_HUMAN 0.265483369363219 7 10 Activating 709 709 missense 26367 EGFR_HUMAN.E709G E709G null EGFR_HUMAN 0.606819129973072 16 10 Activating 709 709 missense 26367 EGFR_HUMAN.S720F S720F EGFR_HUMAN/712-968 EGFR_HUMAN 0.530966738726438 14 10 Activating 720 720 missense 26367 EGFR_HUMAN.E746_T751>VA E746_T751>VA EGFR_HUMAN/712-968 EGFR_HUMAN 0.303409564986536 8 10 Activating 746 751 indel 26367 EGFR_HUMAN.Q812R Q812R EGFR_HUMAN/712-968 EGFR_HUMAN 0.037926195623317 1 10 Activating 812 812 missense 26367 EGFR_HUMAN.R836C R836C EGFR_HUMAN/712-968 EGFR_HUMAN 0.189630978116585 5 10 Activating 836 836 missense 26367 EGFR_HUMAN.E746_S752>V E746_S752>V EGFR_HUMAN/712-968 EGFR_HUMAN 4.85455303978458 128 10 Activating 746 752 indel 26367 EGFR_HUMAN.G779F G779F EGFR_HUMAN/712-968 EGFR_HUMAN 0.113778586869951 3 10 Activating 779 779 missense 26367 EGFR_HUMAN.E746_T751>I E746_T751>I EGFR_HUMAN/712-968 EGFR_HUMAN 0.265483369363219 7 10 Activating 746 751 indel 26367 EGFR_HUMAN.L747_T751>S L747_T751>S EGFR_HUMAN/712-968 EGFR_HUMAN 0.493040543103121 13 10 Activating 747 751 indel 26367 EGFR_HUMAN.N700D N700D null EGFR_HUMAN 0.037926195623317 1 10 Activating 700 700 missense 26367 EGFR_HUMAN.L747_P753>S L747_P753>S EGFR_HUMAN/712-968 EGFR_HUMAN 11.1503015132552 294 10 Activating 747 753 indel 26367 EGFR_HUMAN.E709A E709A null EGFR_HUMAN 1.21363825994614 32 10 Activating 709 709 missense 26367 EGFR_HUMAN.E746_S752>A E746_S752>A EGFR_HUMAN/712-968 EGFR_HUMAN 0.341335760609853 9 10 Activating 746 752 indel 26367 EGFR_HUMAN.P699S P699S null EGFR_HUMAN 0.0758523912466341 2 10 Activating 699 699 missense 26367 EGFR_HUMAN.L747_E749>P L747_E749>P EGFR_HUMAN/712-968 EGFR_HUMAN 0.037926195623317 1 10 Activating 747 749 indel 26367 EGFR_HUMAN.F856L F856L EGFR_HUMAN/712-968 EGFR_HUMAN 0.113778586869951 3 10 Activating 856 856 missense 26367 EGFR_HUMAN.K806E K806E EGFR_HUMAN/712-968 EGFR_HUMAN 0.151704782493268 4 10 Activating 806 806 missense 26367 EGFR_HUMAN.E746_T751>A E746_T751>A EGFR_HUMAN/712-968 EGFR_HUMAN 1.82045738991922 48 10 Activating 746 751 indel 26367 EGFR_HUMAN.L747_P753>Q L747_P753>Q EGFR_HUMAN/712-968 EGFR_HUMAN 0.910228694959609 24 10 Activating 747 753 indel 26367 EGFR_HUMAN.G719C G719C EGFR_HUMAN/712-968 EGFR_HUMAN 3.109948041112 82 10 Activating 719 719 missense 26367 EGFR_HUMAN.L747_T751>Q L747_T751>Q EGFR_HUMAN/712-968 EGFR_HUMAN 0.265483369363219 7 10 Activating 747 751 indel 26367 EGFR_HUMAN.R776C R776C EGFR_HUMAN/712-968 EGFR_HUMAN 0.303409564986536 8 10 Activating 776 776 missense 26367 EGFR_HUMAN.D855G D855G EGFR_HUMAN/712-968 EGFR_HUMAN 0.037926195623317 1 10 Activating 855 855 missense 26367 EGFR_HUMAN.E746_A750>IP E746_A750>IP EGFR_HUMAN/712-968 EGFR_HUMAN 0.303409564986536 8 10 Activating 746 750 indel 26367 EGFR_HUMAN.L861Q L861Q EGFR_HUMAN/712-968 EGFR_HUMAN 14.7532900974703 389 10 Activating 861 861 missense 26367 EGFR_HUMAN.L861R L861R EGFR_HUMAN/712-968 EGFR_HUMAN 0.606819129973072 16 10 Activating 861 861 missense 26367 EGFR_HUMAN.G863D G863D EGFR_HUMAN/712-968 EGFR_HUMAN 0.265483369363219 7 10 Activating 863 863 missense 26367 EGFR_HUMAN.G696E G696E null EGFR_HUMAN 0.037926195623317 1 10 Activating 696 696 missense 26367 EGFR_HUMAN.V765M V765M EGFR_HUMAN/712-968 EGFR_HUMAN 0.341335760609853 9 10 Activating 765 765 missense 26367 EGFR_HUMAN.L747_A750>P L747_A750>P EGFR_HUMAN/712-968 EGFR_HUMAN 6.86464140782038 181 10 Activating 747 750 indel 26367 EGFR_HUMAN.L858R L858R EGFR_HUMAN/712-968 EGFR_HUMAN 377.706982212614 9959 10 Activating 858 858 missense 26367 EGFR_HUMAN.G857R G857R EGFR_HUMAN/712-968 EGFR_HUMAN 0.189630978116585 5 10 Activating 857 857 missense 26367 EGFR_HUMAN.V843I V843I EGFR_HUMAN/712-968 EGFR_HUMAN 0.417188151856487 11 10 Activating 843 843 missense 26367 EGFR_HUMAN.L833V L833V EGFR_HUMAN/712-968 EGFR_HUMAN 1.3274168468161 35 10 Activating 833 833 missense 26367 EGFR_HUMAN.Q701* Q701* null EGFR_HUMAN 0.037926195623317 1 10 Activating 701 701 nonsense 26367 EGFR_HUMAN.E709K E709K null EGFR_HUMAN 1.7825311942959 47 10 Activating 709 709 missense 26367 EGFR_HUMAN.G719A G719A EGFR_HUMAN/712-968 EGFR_HUMAN 6.82671521219706 180 10 Activating 719 719 missense 26367 CSF1R_HUMAN.Y969C Y969C null CSF1R_HUMAN 33.8541666666667 13 11 Activating 969 969 missense 384 CSF1R_HUMAN.Y571D Y571D null CSF1R_HUMAN 2.60416666666667 1 12 Activating 571 571 missense 384 CSF1R_HUMAN.Y969* Y969* null CSF1R_HUMAN 10.4166666666667 4 11 Activating 969 969 nonsense 384 CSF1R_HUMAN.L301F L301F null CSF1R_HUMAN 5.20833333333333 2 11 Activating 301 301 missense 384 CSF1R_HUMAN.Y969H Y969H null CSF1R_HUMAN 7.8125 3 11 Activating 969 969 missense 384 CSF1R_HUMAN.Y969F Y969F null CSF1R_HUMAN 7.8125 3 11 Activating 969 969 missense 384 CSF1R_HUMAN.L301S L301S null CSF1R_HUMAN 10.4166666666667 4 11 Activating 301 301 missense 384 EPHA2_HUMAN.R721Q R721Q EPHA2_HUMAN/613-871 EPHA2_HUMAN 2.84900284900285 1 13 Activating 721 721 missense 351 JAK1_HUMAN.A634D A634D JAK1_HUMAN/583-845 JAK1_HUMAN 4.05679513184584 2 14 Activating 634 634 missense 493 JAK1_HUMAN.V658F V658F JAK1_HUMAN/583-845 JAK1_HUMAN 14.1987829614604 7 15 Activating 658 658 missense 493 ACK1_HUMAN.R99Q R99Q null ACK1_HUMAN 7.16845878136201 2 16 Activating 99 99 missense 279 ACK1_HUMAN.M409I M409I null ACK1_HUMAN 10.752688172043 3 16 Activating 409 409 missense 279 ACK1_HUMAN.E346K E346K ACK1_HUMAN/126-385 ACK1_HUMAN 7.16845878136201 2 16 Activating 346 346 missense 279 ACK1_HUMAN.R34L R34L null ACK1_HUMAN 10.752688172043 3 16 Activating 34 34 missense 279 CHK2_HUMAN.Y327C Y327C CHK2_HUMAN/220-486 CHK2_HUMAN 3.6101083032491 2 17 Inactivating 327 327 missense 554 CHK2_HUMAN.S428F S428F CHK2_HUMAN/220-486 CHK2_HUMAN 1.80505415162455 1 18 Inactivating 428 428 missense 554 CHK2_HUMAN.R145W R145W null CHK2_HUMAN 5.41516245487365 3 18 Inactivating 145 145 missense 554 CHK2_HUMAN.I157T I157T null CHK2_HUMAN 3.6101083032491 2 18 Inactivating 157 157 missense 554 CHK2_HUMAN.R180H R180H null CHK2_HUMAN 1.80505415162455 1 18 Inactivating 180 180 missense 554 PGFRB_HUMAN.R987W R987W null PGFRB_HUMAN 10.1522842639594 4 19 Activating 987 987 missense 394 KPCG_HUMAN.P524R P524R KPCG_HUMAN/351-604 KPCG_HUMAN 3.3112582781457 1 7 Activating 524 524 missense 302 FGFR3_HUMAN.Y373C Y373C null FGFR3_HUMAN 164.726281892494 665 20 Activating 373 373 missense 4037 FGFR3_HUMAN.G697C G697C FGFR3_HUMAN/472-748 FGFR3_HUMAN 10.8991825613079 44 20 Activating 697 697 missense 4037 FGFR3_HUMAN.S371C S371C null FGFR3_HUMAN 17.8350260094129 72 20 Activating 371 371 missense 4037 FGFR3_HUMAN.K650E K650E FGFR3_HUMAN/472-748 FGFR3_HUMAN 21.7983651226158 88 20 Activating 650 650 missense 4037 FGFR3_HUMAN.A391E A391E null FGFR3_HUMAN 10.6514738667327 43 20 Activating 391 391 missense 4037 FGFR3_HUMAN.K650Q K650Q FGFR3_HUMAN/472-748 FGFR3_HUMAN 1.2385434728759 5 21 Activating 650 650 missense 4037 FGFR3_HUMAN.K650M K650M FGFR3_HUMAN/472-748 FGFR3_HUMAN 21.0552390388903 85 20 Activating 650 650 missense 4037 FGFR3_HUMAN.R248C R248C null FGFR3_HUMAN 107.010156056478 432 20 Activating 248 248 missense 4037 FGFR3_HUMAN.K650T K650T FGFR3_HUMAN/472-748 FGFR3_HUMAN 1.2385434728759 5 21 Activating 650 650 missense 4037 FGFR3_HUMAN.G370C G370C null FGFR3_HUMAN 44.5875650235323 180 20 Activating 370 370 missense 4037 FGFR3_HUMAN.S249C S249C null FGFR3_HUMAN 522.913054248204 2111 20 Activating 249 249 missense 4037 ALK_HUMAN.F1245I F1245I ALK_HUMAN/1116-1383 ALK_HUMAN 6.22775800711744 7 22 Activating 1245 1245 missense 1124 ALK_HUMAN.I1171N I1171N ALK_HUMAN/1116-1383 ALK_HUMAN 10.6761565836299 12 22 Activating 1171 1171 missense 1124 ALK_HUMAN.F1174L F1174L ALK_HUMAN/1116-1383 ALK_HUMAN 130.782918149466 147 22 Activating 1174 1174 missense 1124 ALK_HUMAN.F1174C F1174C ALK_HUMAN/1116-1383 ALK_HUMAN 12.4555160142349 14 22 Activating 1174 1174 missense 1124 ALK_HUMAN.F1174V F1174V ALK_HUMAN/1116-1383 ALK_HUMAN 8.00711743772242 9 22 Activating 1174 1174 missense 1124 ALK_HUMAN.G1128A G1128A ALK_HUMAN/1116-1383 ALK_HUMAN 0.889679715302491 1 22 Activating 1128 1128 missense 1124 ALK_HUMAN.Y1278S Y1278S ALK_HUMAN/1116-1383 ALK_HUMAN 5.33807829181495 6 22 Activating 1278 1278 missense 1124 ALK_HUMAN.R1275Q R1275Q ALK_HUMAN/1116-1383 ALK_HUMAN 89.8576512455516 101 22 Activating 1275 1275 missense 1124 ALK_HUMAN.F1245L F1245L ALK_HUMAN/1116-1383 ALK_HUMAN 4.44839857651246 5 22 Activating 1245 1245 missense 1124 ALK_HUMAN.F1174I F1174I ALK_HUMAN/1116-1383 ALK_HUMAN 6.22775800711744 7 22 Activating 1174 1174 missense 1124 ALK_HUMAN.M1166R M1166R ALK_HUMAN/1116-1383 ALK_HUMAN 1.77935943060498 2 22 Activating 1166 1166 missense 1124 RET_HUMAN.M918T M918T RET_HUMAN/724-1005 RET_HUMAN 470.773098680075 749 23 Activating 918 918 missense 1591 RET_HUMAN.C634W C634W null RET_HUMAN 15.7133878064111 25 23 Activating 634 634 missense 1591 RET_HUMAN.E768D E768D RET_HUMAN/724-1005 RET_HUMAN 3.14267756128221 5 23 Activating 768 768 missense 1591 RET_HUMAN.C618Y C618Y null RET_HUMAN 3.14267756128221 5 23 Activating 618 618 missense 1591 RET_HUMAN.C609Y C609Y null RET_HUMAN 0.628535512256442 1 23 Activating 609 609 missense 1591 RET_HUMAN.S891A S891A RET_HUMAN/724-1005 RET_HUMAN 3.14267756128221 5 23 Activating 891 891 missense 1591 RET_HUMAN.C630R C630R null RET_HUMAN 9.42803268384664 15 23 Activating 630 630 missense 1591 RET_HUMAN.C618R C618R null RET_HUMAN 3.14267756128221 5 23 Activating 618 618 missense 1591 RET_HUMAN.A883F A883F RET_HUMAN/724-1005 RET_HUMAN 13.1992457573853 21 23 Activating 883 883 missense 1591 RET_HUMAN.Y791F Y791F RET_HUMAN/724-1005 RET_HUMAN 1.25707102451288 2 23 Activating 791 791 missense 1591 RET_HUMAN.E632_T636>SS E632_T636>SS null RET_HUMAN 8.7994971715902 14 23 Activating 632 636 indel 1591 RET_HUMAN.C634R C634R null RET_HUMAN 30.7982401005657 49 23 Activating 634 634 missense 1591 RET_HUMAN.C634Y C634Y null RET_HUMAN 15.0848522941546 24 23 Activating 634 634 missense 1591 RAF1_HUMAN.T491I T491I RAF1_HUMAN/349-606 RAF1_HUMAN 5.40540540540541 1 24 Activating 491 491 missense 185 RAF1_HUMAN.V263A V263A null RAF1_HUMAN 5.40540540540541 1 24 Activating 263 263 missense 185 RAF1_HUMAN.P261S P261S null RAF1_HUMAN 10.8108108108108 2 24 Activating 261 261 missense 185 RAF1_HUMAN.P261L P261L null RAF1_HUMAN 5.40540540540541 1 24 Activating 261 261 missense 185 RAF1_HUMAN.S257L S257L null RAF1_HUMAN 75.6756756756757 14 24 Activating 257 257 missense 185 RAF1_HUMAN.L613V L613V null RAF1_HUMAN 21.6216216216216 4 24 Activating 613 613 missense 185 RAF1_HUMAN.S259F S259F null RAF1_HUMAN 10.8108108108108 2 24 Activating 259 259 missense 185 TIE2_HUMAN.R849W R849W TIE2_HUMAN/824-1092 TIE2_HUMAN 3.13479623824451 1 25 Activating 849 849 missense 319 TIE2_HUMAN.V919L V919L TIE2_HUMAN/824-1092 TIE2_HUMAN 3.13479623824451 1 25 Activating 919 919 missense 319 ERBB2_HUMAN.P780_Y781insGSP P780_Y781insGSP ERBB2_HUMAN/720-976 ERBB2_HUMAN 9.9889012208657 9 26 Activating 780 781 insertion 901 ERBB2_HUMAN.N857S N857S ERBB2_HUMAN/720-976 ERBB2_HUMAN 3.32963374028857 3 27 Activating 857 857 missense 901 ERBB2_HUMAN.G776>VC G776>VC ERBB2_HUMAN/720-976 ERBB2_HUMAN 12.2086570477248 11 26 Activating 776 776 indel 901 ERBB2_HUMAN.G776>LC G776>LC ERBB2_HUMAN/720-976 ERBB2_HUMAN 4.43951165371809 4 26 Activating 776 776 indel 901 ERBB2_HUMAN.M774_A775insAYVM M774_A775insAYVM ERBB2_HUMAN/720-976 ERBB2_HUMAN 3.32963374028857 3 26 Activating 774 775 insertion 901 ERBB2_HUMAN.G776S G776S ERBB2_HUMAN/720-976 ERBB2_HUMAN 4.43951165371809 4 28 Activating 776 776 missense 901 ERBB2_HUMAN.A775_G776insYVMA A775_G776insYVMA ERBB2_HUMAN/720-976 ERBB2_HUMAN 132.075471698113 119 26 Activating 775 776 insertion 901 EPHA5_HUMAN.G582E G582E null EPHA5_HUMAN 4.85436893203883 3 26 Activating 582 582 missense 618 MET_HUMAN.D1246N D1246N MET_HUMAN/1078-1337 MET_HUMAN 4.67289719626168 4 29 Activating 1246 1246 missense 856 MET_HUMAN.M1268T M1268T MET_HUMAN/1078-1337 MET_HUMAN 14.018691588785 12 29 Activating 1268 1268 missense 856 MET_HUMAN.Y1253D Y1253D MET_HUMAN/1078-1337 MET_HUMAN 54.9065420560748 47 29 Activating 1253 1253 missense 856 MET_HUMAN.Y1248C Y1248C MET_HUMAN/1078-1337 MET_HUMAN 11.6822429906542 10 29 Activating 1248 1248 missense 856 MET_HUMAN.T1010I T1010I null MET_HUMAN 52.5700934579439 45 30 Activating 1010 1010 missense 856 MET_HUMAN.V1110I V1110I MET_HUMAN/1078-1337 MET_HUMAN 3.50467289719626 3 29 Activating 1110 1110 missense 856 MET_HUMAN.Y1248H Y1248H MET_HUMAN/1078-1337 MET_HUMAN 7.00934579439252 6 29 Activating 1248 1248 missense 856 MET_HUMAN.D1246H D1246H MET_HUMAN/1078-1337 MET_HUMAN 3.50467289719626 3 29 Activating 1246 1246 missense 856 MET_HUMAN.N1118Y N1118Y MET_HUMAN/1078-1337 MET_HUMAN 1.16822429906542 1 29 Activating 1118 1118 missense 856 BRAF_HUMAN.G464E G464E BRAF_HUMAN/457-714 BRAF_HUMAN 0.318072480766555 16 31 Activating 464 464 missense 50303 BRAF_HUMAN.T599I T599I BRAF_HUMAN/457-714 BRAF_HUMAN 0.198795300479097 10 31 Activating 599 599 missense 50303 BRAF_HUMAN.V600R V600R BRAF_HUMAN/457-714 BRAF_HUMAN 3.06144762737809 154 31 Activating 600 600 missense 50303 BRAF_HUMAN.L485F L485F BRAF_HUMAN/457-714 BRAF_HUMAN 0.0198795300479097 1 32 Activating 485 485 missense 50303 BRAF_HUMAN.E586K E586K BRAF_HUMAN/457-714 BRAF_HUMAN 0.159036240383277 8 31 Activating 586 586 missense 50303 BRAF_HUMAN.K601E K601E BRAF_HUMAN/457-714 BRAF_HUMAN 3.61807446871956 182 31 Activating 601 601 missense 50303 BRAF_HUMAN.G464V G464V BRAF_HUMAN/457-714 BRAF_HUMAN 0.318072480766555 16 31 Activating 464 464 missense 50303 BRAF_HUMAN.V600K V600K BRAF_HUMAN/457-714 BRAF_HUMAN 21.2114585611196 1067 31 Activating 600 600 missense 50303 BRAF_HUMAN.G469V G469V BRAF_HUMAN/457-714 BRAF_HUMAN 0.775301671868477 39 31 Activating 469 469 missense 50303 BRAF_HUMAN.V600D V600D BRAF_HUMAN/457-714 BRAF_HUMAN 0.755422141820567 38 31 Activating 600 600 missense 50303 BRAF_HUMAN.L597V L597V BRAF_HUMAN/457-714 BRAF_HUMAN 0.298192950718645 15 31 Activating 597 597 missense 50303 BRAF_HUMAN.G469A G469A BRAF_HUMAN/457-714 BRAF_HUMAN 1.59036240383277 80 31 Activating 469 469 missense 50303 BRAF_HUMAN.F595L F595L BRAF_HUMAN/457-714 BRAF_HUMAN 0.258433890622826 13 31 Activating 595 595 missense 50303 BRAF_HUMAN.V600E V600E BRAF_HUMAN/457-714 BRAF_HUMAN 933.701767290221 46968 31 Activating 600 600 missense 50303 STK11_HUMAN.G163C G163C STK11_HUMAN/49-309 STK11_HUMAN 1.77304964539007 1 33 Inactivating 163 163 missense 564 STK11_HUMAN.D194N D194N STK11_HUMAN/49-309 STK11_HUMAN 3.54609929078014 2 26 Inactivating 194 194 missense 564 STK11_HUMAN.T367M T367M null STK11_HUMAN 1.77304964539007 1 null Inactivating 367 367 missense 564 STK11_HUMAN.G242R G242R STK11_HUMAN/49-309 STK11_HUMAN 1.77304964539007 1 26 Inactivating 242 242 missense 564 STK11_HUMAN.G163D G163D STK11_HUMAN/49-309 STK11_HUMAN 1.77304964539007 1 null Inactivating 163 163 missense 564 STK11_HUMAN.F354L F354L null STK11_HUMAN 88.6524822695036 50 33 Inactivating 354 354 missense 564 STK11_HUMAN.N181Y N181Y STK11_HUMAN/49-309 STK11_HUMAN 1.77304964539007 1 null Inactivating 181 181 missense 564 STK11_HUMAN.G171S G171S STK11_HUMAN/49-309 STK11_HUMAN 8.86524822695035 5 null Inactivating 171 171 missense 564 STK11_HUMAN.Q123R Q123R STK11_HUMAN/49-309 STK11_HUMAN 1.77304964539007 1 33 Inactivating 123 123 missense 564 STK11_HUMAN.D194Y D194Y STK11_HUMAN/49-309 STK11_HUMAN 21.2765957446809 12 34 Inactivating 194 194 missense 564 STK11_HUMAN.S216F S216F STK11_HUMAN/49-309 STK11_HUMAN 7.09219858156028 4 26 Inactivating 216 216 missense 564 STK11_HUMAN.P324L P324L null STK11_HUMAN 3.54609929078014 2 35 Inactivating 324 324 missense 564 MP2K2_HUMAN.F57C F57C null MP2K2_HUMAN 13.986013986014 2 32 Activating 57 57 missense 143 JAK3_HUMAN.P132T P132T null JAK3_HUMAN 1.68350168350168 1 36 Activating 132 132 missense 594 JAK3_HUMAN.A572V A572V JAK3_HUMAN/521-777 JAK3_HUMAN 47.1380471380471 28 36 Activating 572 572 missense 594 JAK3_HUMAN.Q501H Q501H null JAK3_HUMAN 13.4680134680135 8 37 Activating 501 501 missense 594 JAK3_HUMAN.V722I V722I JAK3_HUMAN/521-777 JAK3_HUMAN 20.2020202020202 12 36 Activating 722 722 missense 594 JAK3_HUMAN.V715I V715I JAK3_HUMAN/521-777 JAK3_HUMAN 1.68350168350168 1 38 Activating 715 715 missense 594 JAK3_HUMAN.I87T I87T null JAK3_HUMAN 1.68350168350168 1 37 Activating 87 87 missense 594 JAK3_HUMAN.R657Q R657Q JAK3_HUMAN/521-777 JAK3_HUMAN 53.8720538720539 32 37 Activating 657 657 missense 594 EPHB2_HUMAN.G787R G787R EPHB2_HUMAN/621-880 EPHB2_HUMAN null null 39 Inactivating 787 787 missense null PGFRB_HUMAN.D850N D850N PGFRB_HUMAN/600-958 PGFRB_HUMAN 0 null 40 Activating 850 850 missense null PGFRB_HUMAN.T681I T681I PGFRB_HUMAN/600-958 PGFRB_HUMAN 0 null 40 Activating 681 681 missense null PGFRB_HUMAN.P584R P584R null PGFRB_HUMAN null null 41 Activating 584 584 missense null PGFRB_HUMAN.R561C R561C null PGFRB_HUMAN null null 41 Activating 561 561 missense null PGFRB_HUMAN.W566R W566R null PGFRB_HUMAN null null 19 Activating 566 566 missense null PGFRB_HUMAN.L658P L658P PGFRB_HUMAN/600-958 PGFRB_HUMAN null null 19 Activating 658 658 missense null PGFRB_HUMAN.N666K N666K PGFRB_HUMAN/600-958 PGFRB_HUMAN null null 41 Activating 666 666 missense null PGFRB_HUMAN.T681M T681M PGFRB_HUMAN/600-958 PGFRB_HUMAN 0 null 40 Activating 681 681 missense null PGFRB_HUMAN.T681A T681A PGFRB_HUMAN/600-958 PGFRB_HUMAN 0 null 40 Activating 681 681 missense null SRC_HUMAN.E378G E378G SRC_HUMAN/270-519 SRC_HUMAN 0 null 42 Activating 378 378 missense null SRC_HUMAN.Y530* Y530* null SRC_HUMAN 0 null 42 Activating 530 530 nonsense null CHK2_HUMAN.Y390S Y390S CHK2_HUMAN/220-486 CHK2_HUMAN null null 18 Inactivating 390 390 missense null CHK2_HUMAN.T476M T476M CHK2_HUMAN/220-486 CHK2_HUMAN null null 18 Inactivating 476 476 missense null CHK2_HUMAN.R181C R181C null CHK2_HUMAN null null 17 Inactivating 181 181 missense null CHK2_HUMAN.D438Y D438Y CHK2_HUMAN/220-486 CHK2_HUMAN null null 18 Inactivating 438 438 missense null CHK2_HUMAN.R318H R318H CHK2_HUMAN/220-486 CHK2_HUMAN null null 17 Inactivating 318 318 missense null CHK2_HUMAN.D239L D239L CHK2_HUMAN/220-486 CHK2_HUMAN null null 17 Inactivating 239 239 missense null CHK2_HUMAN.K224D K224D CHK2_HUMAN/220-486 CHK2_HUMAN null null 18 Inactivating 224 224 missense null CHK2_HUMAN.T323P T323P CHK2_HUMAN/220-486 CHK2_HUMAN null null 17 Inactivating 323 323 missense null CHK2_HUMAN.I251F I251F CHK2_HUMAN/220-486 CHK2_HUMAN null null 17 Inactivating 251 251 missense null CHK2_HUMAN.E321K E321K CHK2_HUMAN/220-486 CHK2_HUMAN null null 17 Inactivating 321 321 missense null CHK2_HUMAN.D161del D161del null CHK2_HUMAN null null 18 Inactivating 161 161 deletion null MK14_HUMAN.Y323T Y323T null MK14_HUMAN 0 null 40 Activating 323 323 missense null MK14_HUMAN.Y323R Y323R null MK14_HUMAN 0 null 40 Activating 323 323 missense null MK14_HUMAN.Y323Q Y323Q null MK14_HUMAN 0 null 40 Activating 323 323 missense null EPHA2_HUMAN.G391R G391R null EPHA2_HUMAN 0 null 33 Activating 391 391 missense null FGFR4_HUMAN.V550E V550E FGFR4_HUMAN/467-743 FGFR4_HUMAN 0 null 43 Activating 550 550 missense null FGFR4_HUMAN.D535K D535K FGFR4_HUMAN/467-743 FGFR4_HUMAN 0 null 43 Activating 535 535 missense null FGFR4_HUMAN.Y367C Y367C null FGFR4_HUMAN 0 null 44 Activating 367 367 missense null EGFR_HUMAN.E746_A750>P E746_A750>P EGFR_HUMAN/712-968 EGFR_HUMAN 0.02 null 10 Activating 746 750 indel null EGFR_HUMAN.E749Q E749Q EGFR_HUMAN/712-968 EGFR_HUMAN 0 null 10 Activating 749 749 missense null EGFR_HUMAN.E746_T751>D E746_T751>D EGFR_HUMAN/712-968 EGFR_HUMAN 0 null 10 Activating 746 751 indel null EGFR_HUMAN.L747_P753>P L747_P753>P EGFR_HUMAN/712-968 EGFR_HUMAN 0 null 10 Activating 747 753 indel null EGFR_HUMAN.E750P E750P EGFR_HUMAN/712-968 EGFR_HUMAN 0 null 10 Activating 750 750 missense null EGFR_HUMAN.E865L E865L EGFR_HUMAN/712-968 EGFR_HUMAN 0 null 10 Activating 865 865 missense null FLT3_HUMAN.F594_E596 F594_E596 null FLT3_HUMAN 0.02 null 9 Activating 594 596 - null FLT3_HUMAN.F590G F590G null FLT3_HUMAN 0 null 9 Activating 590 590 missense null MP2K1_HUMAN.F53S F53S null MP2K1_HUMAN 0 null 32 Activating 53 53 missense null MP2K1_HUMAN.S218D+S222D S218D+S222D MP2K1_HUMAN/68-361 MP2K1_HUMAN 0 null 40 Activating 218 222 missense null KIT_HUMAN.K558_Y570>R K558_Y570>R null KIT_HUMAN 0 null 0 Activating 558 570 indel null KIT_HUMAN.K558_Y570>NP K558_Y570>NP null KIT_HUMAN 0 null 0 Activating 558 570 indel null MOS_HUMAN.R112G R112G MOS_HUMAN/60-338 MOS_HUMAN 0 null 45 Activating 112 112 missense null PGFRA_HUMAN.V563E V563E null PGFRA_HUMAN null null 46 Activating 563 563 missense null ROR2_HUMAN.Y755* Y755* null ROR2_HUMAN 0 null 47 Activating 755 755 nonsense null ROR2_HUMAN.W749* W749* null ROR2_HUMAN 0 null 47 Activating 749 749 nonsense null FGFR2_HUMAN.K525E K525E FGFR2_HUMAN/481-757 FGFR2_HUMAN 0.4 null 4 Activating 525 525 missense null FGFR2_HUMAN.C342Y C342Y null FGFR2_HUMAN 0 null 48 Activating 342 342 missense null FGFR2_HUMAN.E565A E565A FGFR2_HUMAN/481-757 FGFR2_HUMAN 0 null 4 Activating 565 565 missense null FGFR2_HUMAN.E565G E565G FGFR2_HUMAN/481-757 FGFR2_HUMAN 0 null 4 Activating 565 565 missense null TGFR2_HUMAN.T96I T96I null TGFR2_HUMAN null null 49 Inactivating 96 96 missense null TGFR2_HUMAN.M425V M425V TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 425 425 missense null TGFR2_HUMAN.R528H R528H TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 528 528 missense null TGFR2_HUMAN.C394W C394W TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 394 394 missense null TGFR2_HUMAN.D485K D485K TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 51 Inactivating 485 485 missense null TGFR2_HUMAN.C138R C138R null TGFR2_HUMAN null null 51 Inactivating 138 138 missense null TGFR2_HUMAN.R254H R254H TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 254 254 missense null TGFR2_HUMAN.R460H R460H TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 460 460 missense null TGFR2_HUMAN.P498T P498T TGFR2_HUMAN/244-538 TGFR2_HUMAN null null null Inactivating 498 498 missense null TGFR2_HUMAN.E526Q E526Q TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 52 Inactivating 526 526 missense null TGFR2_HUMAN.R495Q R495Q TGFR2_HUMAN/244-538 TGFR2_HUMAN null null null Inactivating 495 495 missense null TGFR2_HUMAN.L308P L308P TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 308 308 missense null TGFR2_HUMAN.T315M T315M TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 53 Inactivating 315 315 missense null TGFR2_HUMAN.V453E V453E TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 453 453 missense null TGFR2_HUMAN.R537P R537P TGFR2_HUMAN/244-538 TGFR2_HUMAN 0 null 16 Activating 537 537 missense null TGFR2_HUMAN.K327R K327R TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 51 Inactivating 327 327 missense null TGFR2_HUMAN.G357W G357W TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 357 357 missense null TGFR2_HUMAN.P427L P427L TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 427 427 missense null TGFR2_HUMAN.P525R P525R TGFR2_HUMAN/244-538 TGFR2_HUMAN null null null Inactivating 525 525 missense null TGFR2_HUMAN.R528C R528C TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 528 528 missense null TGFR2_HUMAN.R460C R460C TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 460 460 missense null TGFR2_HUMAN.R378G R378G TGFR2_HUMAN/244-538 TGFR2_HUMAN null null null Inactivating 378 378 missense null TGFR2_HUMAN.A355P A355P TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 355 355 missense null TGFR2_HUMAN.Y336N Y336N TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 336 336 missense null TGFR2_HUMAN.S449F S449F TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 449 449 missense null TGFR2_HUMAN.A426T A426T TGFR2_HUMAN/244-538 TGFR2_HUMAN null null null Inactivating 426 426 missense null TGFR2_HUMAN.D446N D446N TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 446 446 missense null TGFR2_HUMAN.H377P H377P TGFR2_HUMAN/244-538 TGFR2_HUMAN null null null Inactivating 377 377 missense null TGFR2_HUMAN.R537C R537C TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 50 Inactivating 537 537 missense null KSYK_HUMAN.Y317F Y317F null KSYK_HUMAN 0 null 40 Activating 317 317 missense null ROCK1_HUMAN.S1126* S1126* null ROCK1_HUMAN 0.98 null 54 Activating 1126 1126 nonsense null ROCK1_HUMAN.P1193S P1193S null ROCK1_HUMAN 0.98 null 54 Activating 1193 1193 missense null ROCK1_HUMAN.Y405* Y405* null ROCK1_HUMAN 0.98 null 54 Activating 405 405 nonsense null KPCD_HUMAN.K376R K376R KPCD_HUMAN/349-603 KPCD_HUMAN null null 40 Inactivating 376 376 missense null KPCD_HUMAN.Y155F Y155F null KPCD_HUMAN null null 40 Inactivating 155 155 missense null MP2K2_HUMAN.S222D+S226D S222D+S226D MP2K2_HUMAN/72-369 MP2K2_HUMAN 0 null 40 Activating 222 226 missense null STK11_HUMAN.T363I T363I null STK11_HUMAN null null 35 Inactivating 363 363 missense null STK11_HUMAN.N181E N181E STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 181 181 missense null STK11_HUMAN.K108_N109del K108_N109del STK11_HUMAN/49-309 STK11_HUMAN null null 35 Inactivating 108 109 deletion null STK11_HUMAN.Q170P Q170P STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 170 170 missense null STK11_HUMAN.Q137_L140del Q137_L140del STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 137 140 deletion null STK11_HUMAN.S232P S232P STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 232 232 missense null STK11_HUMAN.T230P T230P STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 230 230 missense null STK11_HUMAN.K108R K108R STK11_HUMAN/49-309 STK11_HUMAN null null 35 Inactivating 108 108 missense null STK11_HUMAN.I303_H306>N I303_H306>N STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 303 306 indel null STK11_HUMAN.R304W R304W STK11_HUMAN/49-309 STK11_HUMAN null null 35 Inactivating 304 304 missense null STK11_HUMAN.K78I K78I STK11_HUMAN/49-309 STK11_HUMAN null null 35 Inactivating 78 78 missense null STK11_HUMAN.K175_D176del K175_D176del STK11_HUMAN/49-309 STK11_HUMAN null null 35 Inactivating 175 176 deletion null STK11_HUMAN.R86G R86G STK11_HUMAN/49-309 STK11_HUMAN null null 33 Inactivating 86 86 missense null STK11_HUMAN.W239C W239C STK11_HUMAN/49-309 STK11_HUMAN null null 35 Inactivating 239 239 missense null STK11_HUMAN.W308C W308C STK11_HUMAN/49-309 STK11_HUMAN null null 35 Inactivating 308 308 missense null STK11_HUMAN.D176N D176N STK11_HUMAN/49-309 STK11_HUMAN null null 35 Inactivating 176 176 missense null STK11_HUMAN.I303_S307del I303_S307del STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 303 307 deletion null STK11_HUMAN.G215D G215D STK11_HUMAN/49-309 STK11_HUMAN null null 35 Inactivating 215 215 missense null STK11_HUMAN.K78A K78A STK11_HUMAN/49-309 STK11_HUMAN null null 40 Inactivating 78 78 missense null STK11_HUMAN.F157S F157S STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 157 157 missense null STK11_HUMAN.I177N I177N STK11_HUMAN/49-309 STK11_HUMAN null null 35 Inactivating 177 177 missense null STK11_HUMAN.L67P L67P STK11_HUMAN/49-309 STK11_HUMAN null null 35 Inactivating 67 67 missense null BRAF_HUMAN.Q257R Q257R null BRAF_HUMAN 0 null 32 Activating 257 257 missense null BRAF_HUMAN.K499E K499E BRAF_HUMAN/457-714 BRAF_HUMAN 0 null 32 Activating 499 499 missense null BRAF_HUMAN.E501G E501G BRAF_HUMAN/457-714 BRAF_HUMAN 0 null 32 Activating 501 501 missense null BRAF_HUMAN.S467A S467A BRAF_HUMAN/457-714 BRAF_HUMAN 0 null 32 Activating 467 467 missense null TYK2_HUMAN.V678F V678F TYK2_HUMAN/589-866 TYK2_HUMAN 0 null 40 Activating 678 678 missense null BTK_HUMAN.E41K E41K null BTK_HUMAN 0 null 55 Activating 41 41 missense null NTRK1_HUMAN.P203A P203A null NTRK1_HUMAN 0 null 40 Activating 203 203 missense null NTRK1_HUMAN.D668N D668N NTRK1_HUMAN/510-781 NTRK1_HUMAN 0 null 40 Activating 668 668 missense null RAF1_HUMAN.P261A P261A null RAF1_HUMAN 0 null 24 Activating 261 261 missense null TIE2_HUMAN.R915H R915H TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 25 Activating 915 915 missense null TIE2_HUMAN.G743A G743A null TIE2_HUMAN 0 null 56 Activating 743 743 missense null TIE2_HUMAN.Y897F+R915L Y897F+R915L TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 57 Activating 897 915 missense null TIE2_HUMAN.Y897C Y897C TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 25 Activating 897 897 missense null TIE2_HUMAN.K1110N K1110N null TIE2_HUMAN 0 null 25 Activating 1110 1110 missense null TIE2_HUMAN.Y897S Y897S TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 25 Activating 897 897 missense null TIE2_HUMAN.A925S A925S TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 25 Activating 925 925 missense null TIE2_HUMAN.R918C R918C TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 25 Activating 918 918 missense null TIE2_HUMAN.L914F L914F TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 25 Activating 914 914 missense null TIE2_HUMAN.Y897H+R915C Y897H+R915C TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 57 Activating 897 915 missense null TIE2_HUMAN.Y897S+S917I Y897S+S917I TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 57 Activating 897 917 missense null ALK_HUMAN.R1192P R1192P ALK_HUMAN/1116-1383 ALK_HUMAN 0 null 22 Activating 1192 1192 missense null ALK_HUMAN.I1250T I1250T ALK_HUMAN/1116-1383 ALK_HUMAN 0 null 22 Activating 1250 1250 missense null RET_HUMAN.C620Y C620Y null RET_HUMAN 0 null 23 Activating 620 620 missense null RET_HUMAN.Y606C Y606C null RET_HUMAN 0 null 40 Activating 606 606 missense null RET_HUMAN.C634_R635insHGLC C634_R635insHGLC null RET_HUMAN 0 null 23 Activating 634 635 insertion null RET_HUMAN.V804L V804L RET_HUMAN/724-1005 RET_HUMAN 0 null 23 Activating 804 804 missense null RET_HUMAN.V804M+E805K V804M+E805K RET_HUMAN/724-1005 RET_HUMAN 0.22 null 23 Activating 804 805 missense null KPCG_HUMAN.R659S R659S null KPCG_HUMAN 0 null 58 Activating 659 659 missense null FAK1_HUMAN.K38A K38A null FAK1_HUMAN 0 null 40 Activating 38 38 missense null KIT_HUMAN.K558_V560del K558_V560del null KIT_HUMAN 2.01588995612475 17 0 Activating 558 560 deletion 8433 KIT_HUMAN.Q556_V559del Q556_V559del null KIT_HUMAN 0.711490572749911 6 0 Activating 556 559 deletion 8433 KIT_HUMAN.V559_T574del V559_T574del null KIT_HUMAN 0.711490572749911 6 0 Activating 559 574 deletion 8433 KIT_HUMAN.V559_E561del V559_E561del null KIT_HUMAN 1.89730819399976 16 0 Activating 559 561 deletion 8433 KIT_HUMAN.W557_V559del W557_V559del null KIT_HUMAN 2.25305348037472 19 0 Activating 557 559 deletion 8433 KIT_HUMAN.K550_K558del K550_K558del null KIT_HUMAN 7.35206925174908 62 0 Activating 550 558 deletion 8433 KIT_HUMAN.M552_V555del M552_V555del null KIT_HUMAN 1.42298114549982 12 0 Activating 552 555 deletion 8433 KIT_HUMAN.V555_Q556del V555_Q556del null KIT_HUMAN 1.18581762124985 10 0 Activating 555 556 deletion 8433 KIT_HUMAN.V560_L576del V560_L576del null KIT_HUMAN 2.96454405312463 25 0 Activating 560 576 deletion 8433 KIT_HUMAN.M552_Y553del M552_Y553del null KIT_HUMAN 1.77872643187478 15 0 Activating 552 553 deletion 8433 KIT_HUMAN.K558_D572del K558_D572del null KIT_HUMAN 1.06723585912487 9 0 Activating 558 572 deletion 8433 KIT_HUMAN.K558_V559del K558_V559del null KIT_HUMAN 3.2017075773746 27 0 Activating 558 559 deletion 8433 KIT_HUMAN.Y570_L576del Y570_L576del null KIT_HUMAN 2.72738052887466 23 0 Activating 570 576 deletion 8433 KIT_HUMAN.K558_E562del K558_E562del null KIT_HUMAN 2.84596229099964 24 0 Activating 558 562 deletion 8433 KIT_HUMAN.N564_L576del N564_L576del null KIT_HUMAN 1.42298114549982 12 0 Activating 564 576 deletion 8433 KIT_HUMAN.V569_L576del V569_L576del null KIT_HUMAN 2.96454405312463 25 0 Activating 569 576 deletion 8433 KIT_HUMAN.V559del V559del null KIT_HUMAN 4.98043400924938 42 0 Activating 559 559 deletion 8433 KIT_HUMAN.P551_V555del P551_V555del null KIT_HUMAN 2.13447171824973 18 0 Activating 551 555 deletion 8433 KIT_HUMAN.N567_P573del N567_P573del null KIT_HUMAN 0.711490572749911 6 0 Activating 567 573 deletion 8433 KIT_HUMAN.W557_K558del W557_K558del null KIT_HUMAN 55.2591011502431 466 0 Activating 557 558 deletion 8433 KIT_HUMAN.L576del L576del null KIT_HUMAN 1.54156290762481 13 0 Activating 576 576 deletion 8433 KIT_HUMAN.V560del V560del null KIT_HUMAN 7.58923277599905 64 0 Activating 560 560 deletion 8433 KIT_HUMAN.Q556_W557del Q556_W557del null KIT_HUMAN 2.01588995612475 17 0 Activating 556 557 deletion 8433 KIT_HUMAN.E554_K558del E554_K558del null KIT_HUMAN 3.32028933949959 28 0 Activating 554 558 deletion 8433 KIT_HUMAN.V559_G565del V559_G565del null KIT_HUMAN 1.89730819399976 16 0 Activating 559 565 deletion 8433 KIT_HUMAN.V555_V559del V555_V559del null KIT_HUMAN 1.30439938337484 11 0 Activating 555 559 deletion 8433 KIT_HUMAN.P551_Q556del P551_Q556del null KIT_HUMAN 1.06723585912487 9 0 Activating 551 556 deletion 8433 KIT_HUMAN.P551_E554del P551_E554del null KIT_HUMAN 3.32028933949959 28 0 Activating 551 554 deletion 8433 KIT_HUMAN.D579del D579del null KIT_HUMAN 9.6051227321238 81 0 Activating 579 579 deletion 8433 KIT_HUMAN.W557_E561del W557_E561del null KIT_HUMAN 7.11490572749911 60 0 Activating 557 561 deletion 8433 KIT_HUMAN.K550_E554del K550_E554del null KIT_HUMAN 1.30439938337484 11 0 Activating 550 554 deletion 8433 KIT_HUMAN.M552_D572del M552_D572del null KIT_HUMAN 0.474327048499941 4 0 Activating 552 572 deletion 8433 KIT_HUMAN.M552_W557del M552_W557del null KIT_HUMAN 3.08312581524961 26 0 Activating 552 557 deletion 8433 KIT_HUMAN.Y553_K558del Y553_K558del null KIT_HUMAN 2.49021700462469 21 0 Activating 553 558 deletion 8433 KIT_HUMAN.Y553_Q556del Y553_Q556del null KIT_HUMAN 2.49021700462469 21 0 Activating 553 556 deletion 8433 STK11_HUMAN.L182del L182del STK11_HUMAN/49-309 STK11_HUMAN 1.77304964539007 1 26 Inactivating 182 182 deletion 564 STK11_HUMAN.E98_G155del E98_G155del STK11_HUMAN/49-309 STK11_HUMAN 5.31914893617021 3 null Inactivating 98 155 deletion 564 RET_HUMAN.E632_L633del E632_L633del null RET_HUMAN 9.42803268384664 15 23 Activating 632 633 deletion 1591 EGFR_HUMAN.E746_T751del E746_T751del EGFR_HUMAN/712-968 EGFR_HUMAN 1.28949065119278 34 10 Activating 746 751 deletion 26367 EGFR_HUMAN.K745_A750del K745_A750del EGFR_HUMAN/712-968 EGFR_HUMAN 0.834376303712975 22 10 Activating 745 750 deletion 26367 EGFR_HUMAN.E746_S752del E746_S752del EGFR_HUMAN/712-968 EGFR_HUMAN 0.682671521219706 18 10 Activating 746 752 deletion 26367 EGFR_HUMAN.L747_T751del L747_T751del EGFR_HUMAN/712-968 EGFR_HUMAN 7.43353434217014 196 10 Activating 747 751 deletion 26367 EGFR_HUMAN.L747_E749del L747_E749del EGFR_HUMAN/712-968 EGFR_HUMAN 1.06193347745288 28 10 Activating 747 749 deletion 26367 EGFR_HUMAN.E746_A750del E746_A750del EGFR_HUMAN/712-968 EGFR_HUMAN 132.17279174726 3485 10 Activating 746 750 deletion 26367 EGFR_HUMAN.E746_R748del E746_R748del EGFR_HUMAN/712-968 EGFR_HUMAN 0.0758523912466341 2 10 Activating 746 748 deletion 26367 EGFR_HUMAN.E746_E749del E746_E749del EGFR_HUMAN/712-968 EGFR_HUMAN 0.493040543103121 13 10 Activating 746 749 deletion 26367 EGFR_HUMAN.L747_S752del L747_S752del EGFR_HUMAN/712-968 EGFR_HUMAN 3.5650623885918 94 10 Activating 747 752 deletion 26367 EGFR_HUMAN.S752_I759del S752_I759del EGFR_HUMAN/712-968 EGFR_HUMAN 1.02400728182956 27 10 Activating 752 759 deletion 26367 EGFR_HUMAN.L747_P753del L747_P753del EGFR_HUMAN/712-968 EGFR_HUMAN 1.28949065119278 34 10 Activating 747 753 deletion 26367 EGFR_HUMAN.R748_P753del R748_P753del EGFR_HUMAN/712-968 EGFR_HUMAN 0.0758523912466341 2 10 Activating 748 753 deletion 26367 EGFR_HUMAN.K745_E749del K745_E749del EGFR_HUMAN/712-968 EGFR_HUMAN 0.530966738726438 14 10 Activating 745 749 deletion 26367 FLT3_HUMAN.D835_I836del D835_I836del FLT3_HUMAN/610-943 FLT3_HUMAN 0.0589657409045345 1 9 Activating 835 836 deletion 16959 FLT3_HUMAN.I836del I836del FLT3_HUMAN/610-943 FLT3_HUMAN 3.5969101951766 61 9 Activating 836 836 deletion 16959 JAK2_HUMAN.E543_D544del E543_D544del null JAK2_HUMAN 0.800384184408516 40 2 Activating 543 544 deletion 49976 JAK2_HUMAN.N542_E543del N542_E543del null JAK2_HUMAN 1.4006723227149 70 2 Activating 542 543 deletion 49976 PGFRA_HUMAN.M844_S847del M844_S847del PGFRA_HUMAN/593-950 PGFRA_HUMAN 4.40313111545988 9 0 Activating 844 847 deletion 2044 PGFRA_HUMAN.R560_S564del R560_S564del null PGFRA_HUMAN 0.978473581213307 2 0 Activating 560 564 deletion 2044 PGFRA_HUMAN.I843_D846del I843_D846del PGFRA_HUMAN/593-950 PGFRA_HUMAN 24.9510763209393 51 0 Activating 843 846 deletion 2044 PGFRA_HUMAN.D842_H845del D842_H845del PGFRA_HUMAN/593-950 PGFRA_HUMAN 18.1017612524462 37 0 Activating 842 845 deletion 2044 PGFRA_HUMAN.D842_M844del D842_M844del PGFRA_HUMAN/593-950 PGFRA_HUMAN 4.40313111545988 9 0 Activating 842 844 deletion 2044