mutation pfam_domain_id uniprot_id rel_freq abs_freq disease_id validation from_res_n to_res_n mut_type gene_sample_count A391E null FGFR3_HUMAN 2.42687444118023 38 0 Activating 391 391 missense 15658 S249C null FGFR3_HUMAN 112.466470813642 1761 0 Activating 249 249 missense 15658 K650M FGFR3_HUMAN/472-748 FGFR3_HUMAN 5.17307446672627 81 0 Activating 650 650 missense 15658 R248C null FGFR3_HUMAN 24.9073955805339 390 0 Activating 248 248 missense 15658 K650Q FGFR3_HUMAN/472-748 FGFR3_HUMAN 0.319325584365819 5 1 Activating 650 650 missense 15658 S371C null FGFR3_HUMAN 4.47055818112147 70 0 Activating 371 371 missense 15658 K650T FGFR3_HUMAN/472-748 FGFR3_HUMAN 0.319325584365819 5 1 Activating 650 650 missense 15658 Y373C null FGFR3_HUMAN 35.8283305658449 561 0 Activating 373 373 missense 15658 K650E FGFR3_HUMAN/472-748 FGFR3_HUMAN 5.10920934985311 80 0 Activating 650 650 missense 15658 G370C null FGFR3_HUMAN 10.0268233490867 157 0 Activating 370 370 missense 15658 G697C FGFR3_HUMAN/472-748 FGFR3_HUMAN 2.81006514241921 44 0 Activating 697 697 missense 15658 R34L null ACK1_HUMAN 2.04081632653061 2 2 Activating 34 34 missense 980 R99Q null ACK1_HUMAN 1.02040816326531 1 2 Activating 99 99 missense 980 E346K ACK1_HUMAN/126-385 ACK1_HUMAN 1.02040816326531 1 2 Activating 346 346 missense 980 M409I null ACK1_HUMAN 1.02040816326531 1 2 Activating 409 409 missense 980 D697Y TTK_HUMAN/525-791 TTK_HUMAN 0.759878419452888 1 3 Activating 697 697 missense 1316 G582E null EPHA5_HUMAN 0.447027268663388 1 4 Activating 582 582 missense 2237 A634D JAK1_HUMAN/583-845 JAK1_HUMAN 0.373692077727952 2 5 Activating 634 634 missense 5352 V658F JAK1_HUMAN/583-845 JAK1_HUMAN 1.12107623318386 6 6 Activating 658 658 missense 5352 F323L STK33_HUMAN/116-381 STK33_HUMAN 4.40528634361233 2 3 Activating 323 323 missense 454 Y571D null CSF1R_HUMAN 0.322997416020672 1 7 Activating 571 571 missense 3096 L301S null CSF1R_HUMAN 1.29198966408269 4 8 Activating 301 301 missense 3096 Y969C null CSF1R_HUMAN 4.19896640826873 13 8 Activating 969 969 missense 3096 Y969* null CSF1R_HUMAN 1.29198966408269 4 8 Activating 969 969 nonsense 3096 Y969H null CSF1R_HUMAN 0.968992248062015 3 8 Activating 969 969 missense 3096 Y969F null CSF1R_HUMAN 0.968992248062015 3 8 Activating 969 969 missense 3096 L301F null CSF1R_HUMAN 0.645994832041344 2 8 Activating 301 301 missense 3096 S566_E571>K null PGFRA_HUMAN 0.395550061804697 8 9 Activating 566 571 indel 20225 D842_D846>H PGFRA_HUMAN/593-950 PGFRA_HUMAN 0.197775030902349 4 9 Activating 842 846 indel 20225 H845_N848>P PGFRA_HUMAN/593-950 PGFRA_HUMAN 0.148331273176761 3 9 Activating 845 848 indel 20225 D842V PGFRA_HUMAN/593-950 PGFRA_HUMAN 23.3374536464771 472 9 Activating 842 842 missense 20225 D842_D846>E PGFRA_HUMAN/593-950 PGFRA_HUMAN 0.148331273176761 3 9 Activating 842 846 indel 20225 V561D null PGFRA_HUMAN 2.86773794808405 58 9 Activating 561 561 missense 20225 N659K PGFRA_HUMAN/593-950 PGFRA_HUMAN 1.18665018541409 24 9 Activating 659 659 missense 20225 I843_S847>T PGFRA_HUMAN/593-950 PGFRA_HUMAN 0.444993819530284 9 9 Activating 843 847 indel 20225 Y849S PGFRA_HUMAN/593-950 PGFRA_HUMAN 0.0988875154511743 2 10 Activating 849 849 missense 20225 N659Y PGFRA_HUMAN/593-950 PGFRA_HUMAN 0.247218788627936 5 9 Activating 659 659 missense 20225 D842Y PGFRA_HUMAN/593-950 PGFRA_HUMAN 0.593325092707046 12 9 Activating 842 842 missense 20225 S566_E571>R null PGFRA_HUMAN 2.47218788627936 50 9 Activating 566 571 indel 20225 Y849C PGFRA_HUMAN/593-950 PGFRA_HUMAN 0.247218788627936 5 9 Activating 849 849 missense 20225 S1126* null ROCK1_HUMAN 1.04166666666667 1 11 Activating 1126 1126 nonsense 960 Y405fs*1 null ROCK1_HUMAN 1.04166666666667 1 11 Activating 405 405 frameshift 960 P1193S null ROCK1_HUMAN 1.04166666666667 1 11 Activating 1193 1193 missense 960 R683G JAK2_HUMAN/545-805 JAK2_HUMAN 0.565377796943127 59 12 Activating 683 683 missense 104355 T875N JAK2_HUMAN/849-1123 JAK2_HUMAN 0.0191653490489196 2 12 Activating 875 875 missense 104355 H538_K539>L null JAK2_HUMAN 0.153322792391356 16 12 Activating 538 539 indel 104355 I540_E543>MK null JAK2_HUMAN 0.0670787216712184 7 12 Activating 540 543 indel 104355 H538_K539>QL null JAK2_HUMAN 0.0766613961956782 8 12 Activating 538 539 indel 104355 R541_E543>K null JAK2_HUMAN 0.143740117866897 15 12 Activating 541 543 indel 104355 R564L JAK2_HUMAN/545-805 JAK2_HUMAN 0.0479133726222989 5 12 Activating 564 564 missense 104355 V617F JAK2_HUMAN/545-805 JAK2_HUMAN 363.614584830626 37945 12 Activating 617 617 missense 104355 F537_K539>L null JAK2_HUMAN 0.191653490489196 20 12 Activating 537 539 indel 104355 P524R KPCG_HUMAN/351-604 KPCG_HUMAN 0.684931506849315 1 3 Activating 524 524 missense 1460 E746_S752>V EGFR_HUMAN/712-968 EGFR_HUMAN 1.12252740584928 111 13 Activating 746 752 indel 98884 E746_T751>V EGFR_HUMAN/712-968 EGFR_HUMAN 0.121354314145868 12 13 Activating 746 751 indel 98884 P699S null EGFR_HUMAN 0.0101128595121557 1 13 Activating 699 699 missense 98884 T790M EGFR_HUMAN/712-968 EGFR_HUMAN 10.6286153472756 1051 13 Activating 790 790 missense 98884 L747_P753>S EGFR_HUMAN/712-968 EGFR_HUMAN 2.66979491120909 264 13 Activating 747 753 indel 98884 E746_T751>VA EGFR_HUMAN/712-968 EGFR_HUMAN 0.0707900165850896 7 13 Activating 746 751 indel 98884 L747_E749>P EGFR_HUMAN/712-968 EGFR_HUMAN 0.0101128595121557 1 13 Activating 747 749 indel 98884 E746_A750>IP EGFR_HUMAN/712-968 EGFR_HUMAN 0.0809028760972453 8 13 Activating 746 750 indel 98884 E709G null EGFR_HUMAN 0.151692892682335 15 13 Activating 709 709 missense 98884 V843I EGFR_HUMAN/712-968 EGFR_HUMAN 0.101128595121557 10 13 Activating 843 843 missense 98884 G779F EGFR_HUMAN/712-968 EGFR_HUMAN 0.030338578536467 3 13 Activating 779 779 missense 98884 L747_T751>Q EGFR_HUMAN/712-968 EGFR_HUMAN 0.0707900165850896 7 13 Activating 747 751 indel 98884 T751_I759>N EGFR_HUMAN/712-968 EGFR_HUMAN 0.161805752194491 16 13 Activating 751 759 indel 98884 N700D null EGFR_HUMAN 0.030338578536467 3 13 Activating 700 700 missense 98884 D855G EGFR_HUMAN/712-968 EGFR_HUMAN 0.0101128595121557 1 13 Activating 855 855 missense 98884 V765M EGFR_HUMAN/712-968 EGFR_HUMAN 0.0606771570729339 6 13 Activating 765 765 missense 98884 L747_A750>P EGFR_HUMAN/712-968 EGFR_HUMAN 1.62817038145706 161 13 Activating 747 750 indel 98884 G719C EGFR_HUMAN/712-968 EGFR_HUMAN 0.667448727802273 66 13 Activating 719 719 missense 98884 L838P EGFR_HUMAN/712-968 EGFR_HUMAN 0.0404514380486226 4 13 Activating 838 838 missense 98884 R776H EGFR_HUMAN/712-968 EGFR_HUMAN 0.151692892682335 15 13 Activating 776 776 missense 98884 V689M null EGFR_HUMAN 0.0101128595121557 1 13 Activating 689 689 missense 98884 G719S EGFR_HUMAN/712-968 EGFR_HUMAN 1.08207596780066 107 13 Activating 719 719 missense 98884 L861Q EGFR_HUMAN/712-968 EGFR_HUMAN 2.89227782047652 286 13 Activating 861 861 missense 98884 K806E EGFR_HUMAN/712-968 EGFR_HUMAN 0.0404514380486226 4 13 Activating 806 806 missense 98884 L747S EGFR_HUMAN/712-968 EGFR_HUMAN 0.131467173658024 13 13 Activating 747 747 missense 98884 S720F EGFR_HUMAN/712-968 EGFR_HUMAN 0.111241454633712 11 13 Activating 720 720 missense 98884 Q701* null EGFR_HUMAN 0.0101128595121557 1 13 Activating 701 701 nonsense 98884 L833V EGFR_HUMAN/712-968 EGFR_HUMAN 0.293272925852514 29 13 Activating 833 833 missense 98884 R836C EGFR_HUMAN/712-968 EGFR_HUMAN 0.0505642975607783 5 13 Activating 836 836 missense 98884 Q812R EGFR_HUMAN/712-968 EGFR_HUMAN 0.0101128595121557 1 13 Activating 812 812 missense 98884 L861R EGFR_HUMAN/712-968 EGFR_HUMAN 0.151692892682335 15 13 Activating 861 861 missense 98884 G857R EGFR_HUMAN/712-968 EGFR_HUMAN 0.0505642975607783 5 13 Activating 857 857 missense 98884 E746_S752>A EGFR_HUMAN/712-968 EGFR_HUMAN 0.0809028760972453 8 13 Activating 746 752 indel 98884 G719A EGFR_HUMAN/712-968 EGFR_HUMAN 1.51692892682335 150 13 Activating 719 719 missense 98884 E709K null EGFR_HUMAN 0.404514380486226 40 13 Activating 709 709 missense 98884 G696E null EGFR_HUMAN 0.0101128595121557 1 13 Activating 696 696 missense 98884 E709A null EGFR_HUMAN 0.293272925852514 29 13 Activating 709 709 missense 98884 E746_T751>I EGFR_HUMAN/712-968 EGFR_HUMAN 0.0707900165850896 7 13 Activating 746 751 indel 98884 G863D EGFR_HUMAN/712-968 EGFR_HUMAN 0.0606771570729339 6 13 Activating 863 863 missense 98884 L747_P753>Q EGFR_HUMAN/712-968 EGFR_HUMAN 0.202257190243113 20 13 Activating 747 753 indel 98884 A839T EGFR_HUMAN/712-968 EGFR_HUMAN 0.0505642975607783 5 13 Activating 839 839 missense 98884 L747_T751>P EGFR_HUMAN/712-968 EGFR_HUMAN 0.424740099510538 42 13 Activating 747 751 indel 98884 T751_I759>S EGFR_HUMAN/712-968 EGFR_HUMAN 0.030338578536467 3 13 Activating 751 759 indel 98884 F856L EGFR_HUMAN/712-968 EGFR_HUMAN 0.030338578536467 3 13 Activating 856 856 missense 98884 E709V null EGFR_HUMAN 0.0606771570729339 6 13 Activating 709 709 missense 98884 L814P EGFR_HUMAN/712-968 EGFR_HUMAN 0.0404514380486226 4 13 Activating 814 814 missense 98884 R776C EGFR_HUMAN/712-968 EGFR_HUMAN 0.0606771570729339 6 13 Activating 776 776 missense 98884 S768I EGFR_HUMAN/712-968 EGFR_HUMAN 1.48659034828688 147 13 Activating 768 768 missense 98884 L858R EGFR_HUMAN/712-968 EGFR_HUMAN 83.5119938513814 8258 13 Activating 858 858 missense 98884 E746_T751>A EGFR_HUMAN/712-968 EGFR_HUMAN 0.434852959022693 43 13 Activating 746 751 indel 98884 K846R EGFR_HUMAN/712-968 EGFR_HUMAN 0.0101128595121557 1 13 Activating 846 846 missense 98884 L747_T751>S EGFR_HUMAN/712-968 EGFR_HUMAN 0.131467173658024 13 13 Activating 747 751 indel 98884 A197P NEK8_HUMAN/4-258 NEK8_HUMAN 2.37529691211401 1 3 Activating 197 197 missense 421 Y130C MP2K1_HUMAN/68-361 MP2K1_HUMAN 0.144906535284741 1 14 Activating 130 130 missense 6901 G242R STK11_HUMAN/49-309 STK11_HUMAN 0.144822592324403 1 4 Inactivating 242 242 missense 6905 D194N STK11_HUMAN/49-309 STK11_HUMAN 0.289645184648805 2 4 Inactivating 194 194 missense 6905 T367M null STK11_HUMAN 0.144822592324403 1 null Inactivating 367 367 missense 6905 G163D STK11_HUMAN/49-309 STK11_HUMAN 0.144822592324403 1 null Inactivating 163 163 missense 6905 S216F STK11_HUMAN/49-309 STK11_HUMAN 0.434467776973208 3 4 Inactivating 216 216 missense 6905 Q123R STK11_HUMAN/49-309 STK11_HUMAN 0.144822592324403 1 15 Inactivating 123 123 missense 6905 N181Y STK11_HUMAN/49-309 STK11_HUMAN 0.144822592324403 1 null Inactivating 181 181 missense 6905 G163C STK11_HUMAN/49-309 STK11_HUMAN 0.144822592324403 1 15 Inactivating 163 163 missense 6905 D194Y STK11_HUMAN/49-309 STK11_HUMAN 1.30340333091962 9 16 Inactivating 194 194 missense 6905 F354L null STK11_HUMAN 4.05503258508327 28 15 Inactivating 354 354 missense 6905 P324L null STK11_HUMAN 0.144822592324403 1 17 Inactivating 324 324 missense 6905 G171S STK11_HUMAN/49-309 STK11_HUMAN 0.289645184648805 2 null Inactivating 171 171 missense 6905 E586K BRAF_HUMAN/457-714 BRAF_HUMAN 0.0218177454632726 4 18 Activating 586 586 missense 183337 K601E BRAF_HUMAN/457-714 BRAF_HUMAN 0.659986800263995 121 18 Activating 601 601 missense 183337 G469A BRAF_HUMAN/457-714 BRAF_HUMAN 0.305448436485816 56 18 Activating 469 469 missense 183337 G464E BRAF_HUMAN/457-714 BRAF_HUMAN 0.0545443636581814 10 18 Activating 464 464 missense 183337 V600E BRAF_HUMAN/457-714 BRAF_HUMAN 191.592531785728 35126 18 Activating 600 600 missense 183337 V600K BRAF_HUMAN/457-714 BRAF_HUMAN 3.59992800143997 660 18 Activating 600 600 missense 183337 G464V BRAF_HUMAN/457-714 BRAF_HUMAN 0.0654532363898177 12 18 Activating 464 464 missense 183337 F595L BRAF_HUMAN/457-714 BRAF_HUMAN 0.0545443636581814 10 18 Activating 595 595 missense 183337 T599I BRAF_HUMAN/457-714 BRAF_HUMAN 0.0272721818290907 5 18 Activating 599 599 missense 183337 V600R BRAF_HUMAN/457-714 BRAF_HUMAN 0.490899272923632 90 18 Activating 600 600 missense 183337 L485F BRAF_HUMAN/457-714 BRAF_HUMAN 0.00545443636581814 1 19 Activating 485 485 missense 183337 V600D BRAF_HUMAN/457-714 BRAF_HUMAN 0.152724218242908 28 18 Activating 600 600 missense 183337 L597V BRAF_HUMAN/457-714 BRAF_HUMAN 0.0709076727556358 13 18 Activating 597 597 missense 183337 G469V BRAF_HUMAN/457-714 BRAF_HUMAN 0.169087527340362 31 18 Activating 469 469 missense 183337 R1275Q ALK_HUMAN/1116-1383 ALK_HUMAN 4.27099460786931 80 20 Activating 1275 1275 missense 18731 F1174L ALK_HUMAN/1116-1383 ALK_HUMAN 4.16421974267258 78 20 Activating 1174 1174 missense 18731 F1245L ALK_HUMAN/1116-1383 ALK_HUMAN 0.213549730393465 4 20 Activating 1245 1245 missense 18731 Y1278S ALK_HUMAN/1116-1383 ALK_HUMAN 0.106774865196733 2 20 Activating 1278 1278 missense 18731 F1245I ALK_HUMAN/1116-1383 ALK_HUMAN 0.266937162991832 5 20 Activating 1245 1245 missense 18731 F1174C ALK_HUMAN/1116-1383 ALK_HUMAN 0.480486893385297 9 20 Activating 1174 1174 missense 18731 M1166R ALK_HUMAN/1116-1383 ALK_HUMAN 0.0533874325983663 1 20 Activating 1166 1166 missense 18731 I1171N ALK_HUMAN/1116-1383 ALK_HUMAN 0.266937162991832 5 20 Activating 1171 1171 missense 18731 F1174I ALK_HUMAN/1116-1383 ALK_HUMAN 0.160162297795099 3 20 Activating 1174 1174 missense 18731 G1128A ALK_HUMAN/1116-1383 ALK_HUMAN 0.0533874325983663 1 20 Activating 1128 1128 missense 18731 F1174V ALK_HUMAN/1116-1383 ALK_HUMAN 0.266937162991832 5 20 Activating 1174 1174 missense 18731 V715I JAK3_HUMAN/521-777 JAK3_HUMAN 0.223713646532438 1 21 Activating 715 715 missense 4470 V722I JAK3_HUMAN/521-777 JAK3_HUMAN 0.447427293064877 2 22 Activating 722 722 missense 4470 P132T null JAK3_HUMAN 0.223713646532438 1 22 Activating 132 132 missense 4470 R657Q JAK3_HUMAN/521-777 JAK3_HUMAN 4.92170022371365 22 23 Activating 657 657 missense 4470 A572V JAK3_HUMAN/521-777 JAK3_HUMAN 5.8165548098434 26 22 Activating 572 572 missense 4470 Q501H null JAK3_HUMAN 1.56599552572707 7 23 Activating 501 501 missense 4470 I87T null JAK3_HUMAN 0.223713646532438 1 23 Activating 87 87 missense 4470 F594L null FLT3_HUMAN 0.0260064495995007 2 24 Activating 594 594 missense 76904 P606_R607ins15 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 606 607 insertion 76904 E608_N609ins25 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 608 609 insertion 76904 L601_K602ins21 null FLT3_HUMAN 0.039009674399251 3 24 Activating 601 602 insertion 76904 K614_V615ins30 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 614 615 insertion 76904 L601_K602insIREYEYDL null FLT3_HUMAN 0.0130032247997503 1 24 Activating 601 602 insertion 76904 F605_P606ins13 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 605 606 insertion 76904 E598_Y599ins17 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 598 599 insertion 76904 Y597_E598ins10 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 597 598 insertion 76904 L601_K602ins28 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 601 602 insertion 76904 P606_R607ins10 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 606 607 insertion 76904 T582_G583ins14 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 582 583 insertion 76904 E604_F605ins12 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 604 605 insertion 76904 V579A null FLT3_HUMAN 0.0130032247997503 1 24 Activating 579 579 missense 76904 Q580_V581ins* null FLT3_HUMAN 0.0130032247997503 1 24 Activating 580 581 insertion 76904 F612_G613ins35 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 612 613 insertion 76904 E611_F612ins25 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0260064495995007 2 24 Activating 611 612 insertion 76904 R607_E608ins23 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 607 608 insertion 76904 R595_E596ins13 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 595 596 insertion 76904 W603_E604ins21 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 603 604 insertion 76904 D586_N587ins15 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 586 587 insertion 76904 F605_P606insDLKWEF null FLT3_HUMAN 0.0130032247997503 1 24 Activating 605 606 insertion 76904 G613_K614ins17 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0260064495995007 2 24 Activating 613 614 insertion 76904 K614_V615ins35 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 614 615 insertion 76904 E598_Y599ins10 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 598 599 insertion 76904 P606_R607ins12 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 606 607 insertion 76904 E596_Y597ins25 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 596 597 insertion 76904 D600_L601ins24 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 600 601 insertion 76904 L601_K602ins29 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 601 602 insertion 76904 E604_F605ins15 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 604 605 insertion 76904 F612_G613ins16 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0260064495995007 2 24 Activating 612 613 insertion 76904 E596_Y597insYVDFRE null FLT3_HUMAN 0.0130032247997503 1 24 Activating 596 597 insertion 76904 D835N FLT3_HUMAN/610-943 FLT3_HUMAN 0.078019348798502 6 24 Activating 835 835 missense 76904 W603_E604ins10 null FLT3_HUMAN 0.039009674399251 3 24 Activating 603 604 insertion 76904 F594_R595ins14 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 594 595 insertion 76904 E608_N609ins19 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 608 609 insertion 76904 I836M FLT3_HUMAN/610-943 FLT3_HUMAN 0.0910225735982524 7 24 Activating 836 836 missense 76904 E598_Y599insDFREYE null FLT3_HUMAN 0.0130032247997503 1 24 Activating 598 599 insertion 76904 K602_W603ins12 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 602 603 insertion 76904 R595_E596ins17 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 595 596 insertion 76904 Y599_D600ins14 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 599 600 insertion 76904 K614_V615ins36 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 614 615 insertion 76904 D600_L601ins10 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 600 601 insertion 76904 D600_L601insRGYEYD null FLT3_HUMAN 0.0130032247997503 1 24 Activating 600 601 insertion 76904 I836D FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 836 836 missense 76904 E596_Y597insRTDFRE null FLT3_HUMAN 0.0130032247997503 1 24 Activating 596 597 insertion 76904 V592_D593insG null FLT3_HUMAN 0.0130032247997503 1 24 Activating 592 593 insertion 76904 N609_L610ins27 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 609 610 insertion 76904 Y597_E598ins18 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 597 598 insertion 76904 E598_Y599ins25 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 598 599 insertion 76904 E611_F612ins27 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 611 612 insertion 76904 L601_K602insEYEYDL null FLT3_HUMAN 0.0130032247997503 1 24 Activating 601 602 insertion 76904 L601_K602ins33 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 601 602 insertion 76904 R595_E596ins12 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 595 596 insertion 76904 E604_F605ins23 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 604 605 insertion 76904 E598_Y599ins22 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 598 599 insertion 76904 F612_G613ins28 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 612 613 insertion 76904 K602_W603ins14 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 602 603 insertion 76904 L601_K602ins11 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 601 602 insertion 76904 Y597_E598ins17 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 597 598 insertion 76904 E611_F612ins22 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 611 612 insertion 76904 E604_F605ins22 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 604 605 insertion 76904 Y599_D600insEYEYEYEY null FLT3_HUMAN 0.039009674399251 3 24 Activating 599 600 insertion 76904 L601_K602ins27 null FLT3_HUMAN 0.0520128991990014 4 24 Activating 601 602 insertion 76904 L601_K602ins24 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 601 602 insertion 76904 V592_D593ins14 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 592 593 insertion 76904 Q580_V581ins12 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 580 581 insertion 76904 I836H FLT3_HUMAN/610-943 FLT3_HUMAN 0.0910225735982524 7 24 Activating 836 836 missense 76904 F590_E596>LG null FLT3_HUMAN 0.0130032247997503 1 24 Activating 590 596 indel 76904 L601_K602ins15 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 601 602 insertion 76904 D593_F594insNEYFYVD null FLT3_HUMAN 0.0130032247997503 1 24 Activating 593 594 insertion 76904 E604_F605insYDLKWE null FLT3_HUMAN 0.0130032247997503 1 24 Activating 604 605 insertion 76904 N676K FLT3_HUMAN/610-943 FLT3_HUMAN 0.0260064495995007 2 24 Activating 676 676 missense 76904 I836S FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 836 836 missense 76904 E598_Y599insFYVDFREYE null FLT3_HUMAN 0.0130032247997503 1 24 Activating 598 599 insertion 76904 N841K FLT3_HUMAN/610-943 FLT3_HUMAN 0.0260064495995007 2 24 Activating 841 841 missense 76904 F612_G613ins15 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 612 613 insertion 76904 F612_G613ins25 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 612 613 insertion 76904 G613_K614ins22 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 613 614 insertion 76904 D835A FLT3_HUMAN/610-943 FLT3_HUMAN 0.078019348798502 6 24 Activating 835 835 missense 76904 W603_E604insYEYDLKW null FLT3_HUMAN 0.0130032247997503 1 24 Activating 603 604 insertion 76904 I836L FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 836 836 missense 76904 V592_D593ins20 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 592 593 insertion 76904 G613_K614ins28 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 613 614 insertion 76904 Y597_E598ins13 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 597 598 insertion 76904 P606_R607ins21 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 606 607 insertion 76904 Y591C null FLT3_HUMAN 0.0130032247997503 1 24 Activating 591 591 missense 76904 F594_R595ins10 null FLT3_HUMAN 0.039009674399251 3 24 Activating 594 595 insertion 76904 G613_K614ins16 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0260064495995007 2 24 Activating 613 614 insertion 76904 Y599_D600ins13 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 599 600 insertion 76904 E598_Y599ins14 null FLT3_HUMAN 0.039009674399251 3 24 Activating 598 599 insertion 76904 E598_Y599insE null FLT3_HUMAN 0.0130032247997503 1 24 Activating 598 599 insertion 76904 D835H FLT3_HUMAN/610-943 FLT3_HUMAN 0.585145115988765 45 24 Activating 835 835 missense 76904 I836V FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 836 836 missense 76904 Y597_E598ins26 null FLT3_HUMAN 0.0520128991990014 4 24 Activating 597 598 insertion 76904 F590_F594>L null FLT3_HUMAN 0.0130032247997503 1 24 Activating 590 594 indel 76904 D600_L601ins26 null FLT3_HUMAN 0.0520128991990014 4 24 Activating 600 601 insertion 76904 F605_P606ins23 null FLT3_HUMAN 0.039009674399251 3 24 Activating 605 606 insertion 76904 L610_E611ins37 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 610 611 insertion 76904 K602_W603insYEYDLK null FLT3_HUMAN 0.0650161239987517 5 24 Activating 602 603 insertion 76904 D600_L601ins12 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 600 601 insertion 76904 Y597_E598ins16 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 597 598 insertion 76904 E608_N609ins11 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 608 609 insertion 76904 L601_K602ins18 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 601 602 insertion 76904 K602_W603ins23 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 602 603 insertion 76904 Y599_D600insFREYEY null FLT3_HUMAN 0.0130032247997503 1 24 Activating 599 600 insertion 76904 E598_Y599ins19 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 598 599 insertion 76904 D593_F594ins16 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 593 594 insertion 76904 E596_Y597ins11 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 596 597 insertion 76904 E611_F612ins13 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 611 612 insertion 76904 Y599_D600ins26 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 599 600 insertion 76904 P606_R607ins17 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 606 607 insertion 76904 D593_F594ins11 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 593 594 insertion 76904 W603_E604ins14 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 603 604 insertion 76904 F590_D593>PCEN null FLT3_HUMAN 0.0130032247997503 1 24 Activating 590 593 indel 76904 Y599_D600insYVDFREYEY null FLT3_HUMAN 0.0130032247997503 1 24 Activating 599 600 insertion 76904 E604_F605ins26 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 604 605 insertion 76904 P606_R607ins26 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 606 607 insertion 76904 E608_N609ins23 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 608 609 insertion 76904 Y599_D600ins32 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 599 600 insertion 76904 E608_N609insI* null FLT3_HUMAN 0.0130032247997503 1 24 Activating 608 609 insertion 76904 V592A null FLT3_HUMAN 0.039009674399251 3 24 Activating 592 592 missense 76904 D600_L601ins22 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 600 601 insertion 76904 F612_G613ins17 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 612 613 insertion 76904 L601_K602ins20 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 601 602 insertion 76904 E604_F605ins10 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 604 605 insertion 76904 D835I FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 835 835 missense 76904 F590_Y591ins13 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 590 591 insertion 76904 R595_E596insDFYVDFR null FLT3_HUMAN 0.0130032247997503 1 24 Activating 595 596 insertion 76904 E598_Y599insDYVDFREYE null FLT3_HUMAN 0.0130032247997503 1 24 Activating 598 599 insertion 76904 I836F FLT3_HUMAN/610-943 FLT3_HUMAN 0.0260064495995007 2 24 Activating 836 836 missense 76904 F590_Y591ins* null FLT3_HUMAN 0.0130032247997503 1 24 Activating 590 591 insertion 76904 L610_E611ins25 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 610 611 insertion 76904 W603_E604ins11 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 603 604 insertion 76904 L610_E611ins19 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 610 611 insertion 76904 P606_R607ins13 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 606 607 insertion 76904 L610_E611ins21 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 610 611 insertion 76904 D600_L601ins21 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 600 601 insertion 76904 E596_Y597ins23 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 596 597 insertion 76904 L601_K602insREYEYDL null FLT3_HUMAN 0.0650161239987517 5 24 Activating 601 602 insertion 76904 F594_R595ins15 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 594 595 insertion 76904 G613_K614ins23 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 613 614 insertion 76904 Y591_V592ins10 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 591 592 insertion 76904 D835E FLT3_HUMAN/610-943 FLT3_HUMAN 0.533132216789764 41 24 Activating 835 835 missense 76904 F605_P606ins22 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 605 606 insertion 76904 F605_P606ins11 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 605 606 insertion 76904 F612_G613ins18 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 612 613 insertion 76904 G613_K614ins15 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 613 614 insertion 76904 Y599_D600ins12 null FLT3_HUMAN 0.039009674399251 3 24 Activating 599 600 insertion 76904 F612_G613ins24 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 612 613 insertion 76904 N841H FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 841 841 missense 76904 D600_L601ins20 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 600 601 insertion 76904 F612_G613ins30 FLT3_HUMAN/610-943 FLT3_HUMAN 0.039009674399251 3 24 Activating 612 613 insertion 76904 L610_E611ins32 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 610 611 insertion 76904 F594_R595ins12 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 594 595 insertion 76904 F612_G613ins34 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 612 613 insertion 76904 L610_E611ins20 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 610 611 insertion 76904 E598_Y599ins20 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 598 599 insertion 76904 D593_F594insWGYFYVD null FLT3_HUMAN 0.0130032247997503 1 24 Activating 593 594 insertion 76904 E611_F612ins23 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 611 612 insertion 76904 F590_Y591insDNEYF null FLT3_HUMAN 0.0130032247997503 1 24 Activating 590 591 insertion 76904 W603_E604ins13 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 603 604 insertion 76904 D835V FLT3_HUMAN/610-943 FLT3_HUMAN 0.637158015187767 49 24 Activating 835 835 missense 76904 F612_G613ins23 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 612 613 insertion 76904 P606_R607ins29 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 606 607 insertion 76904 D600_L601ins14 null FLT3_HUMAN 0.039009674399251 3 24 Activating 600 601 insertion 76904 G613_K614ins33 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 613 614 insertion 76904 L610_E611ins64 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 610 611 insertion 76904 L601_K602insQRI* null FLT3_HUMAN 0.0130032247997503 1 24 Activating 601 602 insertion 76904 N609_L610ins10 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 609 610 insertion 76904 D600_L601ins17 null FLT3_HUMAN 0.0650161239987517 5 24 Activating 600 601 insertion 76904 D600_L601insVDFREYEYD null FLT3_HUMAN 0.0130032247997503 1 24 Activating 600 601 insertion 76904 E598_Y599ins21 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 598 599 insertion 76904 F605_P606insGEYDLKWEF null FLT3_HUMAN 0.0130032247997503 1 24 Activating 605 606 insertion 76904 K602_W603ins17 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 602 603 insertion 76904 K663Q FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 663 663 missense 76904 P606_R607insYDLKWEFP null FLT3_HUMAN 0.0130032247997503 1 24 Activating 606 607 insertion 76904 D600_L601insFREYEYD null FLT3_HUMAN 0.169041922396754 13 24 Activating 600 601 insertion 76904 N609_L610ins19 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 609 610 insertion 76904 Y597_E598ins11 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 597 598 insertion 76904 L610_E611ins26 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 610 611 insertion 76904 E608_N609ins12 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 608 609 insertion 76904 E596_Y597ins16 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 596 597 insertion 76904 R595_E596insNEYFYVDFR null FLT3_HUMAN 0.0130032247997503 1 24 Activating 595 596 insertion 76904 D839G FLT3_HUMAN/610-943 FLT3_HUMAN 0.0260064495995007 2 24 Activating 839 839 missense 76904 L610_E611ins11 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 610 611 insertion 76904 E604_F605ins24 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 604 605 insertion 76904 R595_E596ins10 null FLT3_HUMAN 0.039009674399251 3 24 Activating 595 596 insertion 76904 K614_V615ins15 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 614 615 insertion 76904 E598_Y599insFDFREYE null FLT3_HUMAN 0.0130032247997503 1 24 Activating 598 599 insertion 76904 D593_F594ins12 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 593 594 insertion 76904 W603_E604ins22 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 603 604 insertion 76904 Y599_D600insDFREYEY null FLT3_HUMAN 0.0130032247997503 1 24 Activating 599 600 insertion 76904 N587_E588ins30 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 587 588 insertion 76904 L610_E611ins13 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 610 611 insertion 76904 E604_F605ins21 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 604 605 insertion 76904 F590_Y591insFQRI* null FLT3_HUMAN 0.0130032247997503 1 24 Activating 590 591 insertion 76904 F612_G613ins20 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0650161239987517 5 24 Activating 612 613 insertion 76904 Y591_V592ins23 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 591 592 insertion 76904 Y599_D600ins20 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 599 600 insertion 76904 E608_N609ins31 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 608 609 insertion 76904 L610_E611ins17 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 610 611 insertion 76904 E596_Y597ins12 null FLT3_HUMAN 0.039009674399251 3 24 Activating 596 597 insertion 76904 D835F FLT3_HUMAN/610-943 FLT3_HUMAN 0.0520128991990014 4 24 Activating 835 835 missense 76904 Y599_D600ins11 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 599 600 insertion 76904 F590_Y591>GD null FLT3_HUMAN 0.0130032247997503 1 24 Activating 590 591 indel 76904 D600_L601ins28 null FLT3_HUMAN 0.0130032247997503 1 24 Activating 600 601 insertion 76904 D835Y FLT3_HUMAN/610-943 FLT3_HUMAN 3.58889004473109 276 24 Activating 835 835 missense 76904 Y597_E598insDYVDFREY null FLT3_HUMAN 0.0260064495995007 2 24 Activating 597 598 insertion 76904 Y599_D600ins19 null FLT3_HUMAN 0.0520128991990014 4 24 Activating 599 600 insertion 76904 E596_Y597ins22 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 596 597 insertion 76904 Y599_D600insR* null FLT3_HUMAN 0.0130032247997503 1 24 Activating 599 600 insertion 76904 Y599_D600ins15 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 599 600 insertion 76904 K602_W603ins20 null FLT3_HUMAN 0.0260064495995007 2 24 Activating 602 603 insertion 76904 L610_E611ins18 FLT3_HUMAN/610-943 FLT3_HUMAN 0.0130032247997503 1 24 Activating 610 611 insertion 76904 I157T null CHK2_HUMAN 0.457875457875458 1 25 Inactivating 157 157 missense 2184 Y327C CHK2_HUMAN/220-486 CHK2_HUMAN 0.457875457875458 1 26 Inactivating 327 327 missense 2184 R180H null CHK2_HUMAN 0.457875457875458 1 25 Inactivating 180 180 missense 2184 S428F CHK2_HUMAN/220-486 CHK2_HUMAN 0.457875457875458 1 25 Inactivating 428 428 missense 2184 S372C null FGFR2_HUMAN 0.15460729746444 1 27 Activating 372 372 missense 6468 K659E FGFR2_HUMAN/481-757 FGFR2_HUMAN 1.08225108225108 7 27 Activating 659 659 missense 6468 Y375C null FGFR2_HUMAN 1.5460729746444 10 27 Activating 375 375 missense 6468 S252W null FGFR2_HUMAN 7.57575757575758 49 28 Activating 252 252 missense 6468 N549H FGFR2_HUMAN/481-757 FGFR2_HUMAN 0.463821892393321 3 27 Activating 549 549 missense 6468 K659N FGFR2_HUMAN/481-757 FGFR2_HUMAN 0.463821892393321 3 27 Activating 659 659 missense 6468 N549K FGFR2_HUMAN/481-757 FGFR2_HUMAN 4.48361162646877 29 27 Activating 549 549 missense 6468 C618R null RET_HUMAN 0.170444861087438 3 29 Activating 618 618 missense 17601 C634W null RET_HUMAN 0.795409351741378 14 29 Activating 634 634 missense 17601 C630R null RET_HUMAN 0.62496449065394 11 29 Activating 630 630 missense 17601 E768D RET_HUMAN/724-1005 RET_HUMAN 0.227259814783251 4 29 Activating 768 768 missense 17601 C618Y null RET_HUMAN 0.170444861087438 3 29 Activating 618 618 missense 17601 C609Y null RET_HUMAN 0.0568149536958127 1 29 Activating 609 609 missense 17601 M918T RET_HUMAN/724-1005 RET_HUMAN 26.9302880518152 474 29 Activating 918 918 missense 17601 Y791F RET_HUMAN/724-1005 RET_HUMAN 0.113629907391625 2 29 Activating 791 791 missense 17601 C634R null RET_HUMAN 1.76126356457019 31 29 Activating 634 634 missense 17601 C634Y null RET_HUMAN 0.909039259133004 16 29 Activating 634 634 missense 17601 E632_T636>SS null RET_HUMAN 0.795409351741378 14 29 Activating 632 636 indel 17601 A883F RET_HUMAN/724-1005 RET_HUMAN 0.795409351741378 14 29 Activating 883 883 missense 17601 G776>VC ERBB2_HUMAN/720-976 ERBB2_HUMAN 0.506468990285004 11 4 Activating 776 776 indel 21719 P780_Y781insGSP ERBB2_HUMAN/720-976 ERBB2_HUMAN 0.368341083843639 8 4 Activating 780 781 insertion 21719 M774_A775insAYVM ERBB2_HUMAN/720-976 ERBB2_HUMAN 0.138127906441365 3 4 Activating 774 775 insertion 21719 G776>LC ERBB2_HUMAN/720-976 ERBB2_HUMAN 0.138127906441365 3 4 Activating 776 776 indel 21719 N857S ERBB2_HUMAN/720-976 ERBB2_HUMAN 0.0920852709609098 2 30 Activating 857 857 missense 21719 A775_G776insYVMA ERBB2_HUMAN/720-976 ERBB2_HUMAN 3.36111239007321 73 4 Activating 775 776 insertion 21719 G776S ERBB2_HUMAN/720-976 ERBB2_HUMAN 0.0920852709609098 2 31 Activating 776 776 missense 21719 D1246H MET_HUMAN/1078-1337 MET_HUMAN 0.0930232558139535 1 32 Activating 1246 1246 missense 10750 Y1253D MET_HUMAN/1078-1337 MET_HUMAN 4.37209302325581 47 32 Activating 1253 1253 missense 10750 Y1248H MET_HUMAN/1078-1337 MET_HUMAN 0.186046511627907 2 32 Activating 1248 1248 missense 10750 V1110I MET_HUMAN/1078-1337 MET_HUMAN 0.0930232558139535 1 32 Activating 1110 1110 missense 10750 N1118Y MET_HUMAN/1078-1337 MET_HUMAN 0.0930232558139535 1 32 Activating 1118 1118 missense 10750 M1268T MET_HUMAN/1078-1337 MET_HUMAN 0.837209302325581 9 32 Activating 1268 1268 missense 10750 T1010I null MET_HUMAN 2.6046511627907 28 33 Activating 1010 1010 missense 10750 Y1248C MET_HUMAN/1078-1337 MET_HUMAN 0.930232558139535 10 32 Activating 1248 1248 missense 10750 M552_V559>I null KIT_HUMAN 0.276200705846248 9 9 Activating 552 559 indel 32585 W557_K558>C null KIT_HUMAN 0.0613779346324996 2 9 Activating 557 558 indel 32585 L576P null KIT_HUMAN 5.58539205155746 182 9 Activating 576 576 missense 32585 Y503_F504insAY null KIT_HUMAN 11.9073193187049 388 9 Activating 503 504 insertion 32585 K550_V555>I null KIT_HUMAN 0.184133803897499 6 9 Activating 550 555 indel 32585 D816V KIT_HUMAN/589-924 KIT_HUMAN 44.100046033451 1437 34 Activating 816 816 missense 32585 P585_R586ins12 null KIT_HUMAN 0.245511738529998 8 9 Activating 585 586 insertion 32585 V559A null KIT_HUMAN 2.36305048335124 77 9 Activating 559 559 missense 32585 Y553_E561>LK null KIT_HUMAN 0.0613779346324996 2 9 Activating 553 561 indel 32585 P585_R586insLPYDHKWEFP null KIT_HUMAN 0.0306889673162498 1 9 Activating 585 586 insertion 32585 K581_W582insDPTQLPYDH null KIT_HUMAN 0.0306889673162498 1 9 Activating 581 582 insertion 32585 W557_K558>E null KIT_HUMAN 0.245511738529998 8 9 Activating 557 558 indel 32585 D579_H580insIDPTQLPYD null KIT_HUMAN 0.276200705846248 9 9 Activating 579 580 insertion 32585 W557_K558>F null KIT_HUMAN 0.0613779346324996 2 9 Activating 557 558 indel 32585 E583_F584insPYDHKWE null KIT_HUMAN 0.0613779346324996 2 9 Activating 583 584 insertion 32585 V560D null KIT_HUMAN 5.24781341107872 171 9 Activating 560 560 missense 32585 K558Q null KIT_HUMAN 0.0613779346324996 2 9 Activating 558 558 missense 32585 W557S null KIT_HUMAN 0.122755869264999 4 9 Activating 557 557 missense 32585 K642E KIT_HUMAN/589-924 KIT_HUMAN 3.00751879699248 98 34 Activating 642 642 missense 32585 R586_N587ins13 null KIT_HUMAN 0.429645542427497 14 9 Activating 586 587 insertion 32585 H580_K581insPYDH null KIT_HUMAN 0.122755869264999 4 9 Activating 580 581 insertion 32585 V560G null KIT_HUMAN 0.859291084854995 28 9 Activating 560 560 missense 32585 P551_M552>L null KIT_HUMAN 0.306889673162498 10 9 Activating 551 552 indel 32585 W557G null KIT_HUMAN 1.56513733312874 51 9 Activating 557 557 missense 32585 V559G null KIT_HUMAN 1.35031456191499 44 9 Activating 559 559 missense 32585 E554_D572>A null KIT_HUMAN 0.0920669019487494 3 9 Activating 554 572 indel 32585 M552_E554>K null KIT_HUMAN 0.276200705846248 9 9 Activating 552 554 indel 32585 K558N null KIT_HUMAN 0.398956575111247 13 9 Activating 558 558 missense 32585 D816H KIT_HUMAN/589-924 KIT_HUMAN 2.14822771213749 70 34 Activating 816 816 missense 32585 V559D null KIT_HUMAN 6.90501764615621 225 9 Activating 559 559 missense 32585 F591_G592ins15 KIT_HUMAN/589-924 KIT_HUMAN 0.276200705846248 9 9 Activating 591 592 insertion 32585 K558E null KIT_HUMAN 0.153444836581249 5 9 Activating 558 558 missense 32585 W557R null KIT_HUMAN 3.49854227405248 114 9 Activating 557 557 missense 32585 W557C null KIT_HUMAN 0.214822771213749 7 9 Activating 557 557 missense 32585 K558_Y570>N null KIT_HUMAN 0.0613779346324996 2 9 Activating 558 570 indel 32585 V560E null KIT_HUMAN 0.644468313641246 21 9 Activating 560 560 missense 32585 D816Y KIT_HUMAN/589-924 KIT_HUMAN 2.48580635261623 81 34 Activating 816 816 missense 32585 L589_S590ins15 KIT_HUMAN/589-924 KIT_HUMAN 0.122755869264999 4 9 Activating 589 590 insertion 32585 W557F null KIT_HUMAN 0.0306889673162498 1 9 Activating 557 557 missense 32585 Q556_V559>H null KIT_HUMAN 0.245511738529998 8 9 Activating 556 559 indel 32585 L613V null RAF1_HUMAN 1.77725118483412 3 35 Activating 613 613 missense 1688 S257L null RAF1_HUMAN 5.33175355450237 9 35 Activating 257 257 missense 1688 S259F null RAF1_HUMAN 0.592417061611374 1 35 Activating 259 259 missense 1688 Y367C null FGFR4_HUMAN 0 null 36 Activating 367 367 missense null V550E FGFR4_HUMAN/467-743 FGFR4_HUMAN 0 null 37 Activating 550 550 missense null D535K FGFR4_HUMAN/467-743 FGFR4_HUMAN 0 null 37 Activating 535 535 missense null Y755* null ROR2_HUMAN 0 null 38 Activating 755 755 nonsense null W749* null ROR2_HUMAN 0 null 38 Activating 749 749 nonsense null C138R null TGFR2_HUMAN null null 39 Inactivating 138 138 missense null R528H TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 528 528 missense null A355P TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 355 355 missense null P525R TGFR2_HUMAN/244-538 TGFR2_HUMAN null null null Inactivating 525 525 missense null P498T TGFR2_HUMAN/244-538 TGFR2_HUMAN null null null Inactivating 498 498 missense null T315M TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 41 Inactivating 315 315 missense null A426T TGFR2_HUMAN/244-538 TGFR2_HUMAN null null null Inactivating 426 426 missense null K327R TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 39 Inactivating 327 327 missense null M425V TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 425 425 missense null R378G TGFR2_HUMAN/244-538 TGFR2_HUMAN null null null Inactivating 378 378 missense null T96I null TGFR2_HUMAN null null 42 Inactivating 96 96 missense null Y336N TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 336 336 missense null L308P TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 308 308 missense null E526Q TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 43 Inactivating 526 526 missense null V453E TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 453 453 missense null R460H TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 460 460 missense null R495Q TGFR2_HUMAN/244-538 TGFR2_HUMAN null null null Inactivating 495 495 missense null R254H TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 254 254 missense null D446N TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 446 446 missense null P427L TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 427 427 missense null G357W TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 357 357 missense null S449F TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 449 449 missense null R528C TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 528 528 missense null H377P TGFR2_HUMAN/244-538 TGFR2_HUMAN null null null Inactivating 377 377 missense null R537P TGFR2_HUMAN/244-538 TGFR2_HUMAN 0 null 2 Activating 537 537 missense null C394W TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 394 394 missense null R537C TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 537 537 missense null R460C TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 40 Inactivating 460 460 missense null D485K TGFR2_HUMAN/244-538 TGFR2_HUMAN null null 39 Inactivating 485 485 missense null R112G MOS_HUMAN/60-338 MOS_HUMAN 0 null 44 Activating 112 112 missense null R721Q EPHA2_HUMAN/613-871 EPHA2_HUMAN 0 null 45 Activating 721 721 missense null G391R null EPHA2_HUMAN 0 null 15 Activating 391 391 missense null T681M PGFRB_HUMAN/600-958 PGFRB_HUMAN 0 null 46 Activating 681 681 missense null T681A PGFRB_HUMAN/600-958 PGFRB_HUMAN 0 null 46 Activating 681 681 missense null D850N PGFRB_HUMAN/600-958 PGFRB_HUMAN 0 null 46 Activating 850 850 missense null T681I PGFRB_HUMAN/600-958 PGFRB_HUMAN 0 null 46 Activating 681 681 missense null K1110N null TIE2_HUMAN 0 null 47 Activating 1110 1110 missense null Y897S+S917I TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 48 Activating 897 917 missense null A925S TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 47 Activating 925 925 missense null R918C TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 47 Activating 918 918 missense null R915H TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 47 Activating 915 915 missense null L914F TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 47 Activating 914 914 missense null G743A null TIE2_HUMAN 0 null 49 Activating 743 743 missense null Y897F+R915L TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 48 Activating 897 915 missense null Y897H+R915C TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 48 Activating 897 915 missense null R849W TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 47 Activating 849 849 missense null V919L TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 47 Activating 919 919 missense null Y897C TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 47 Activating 897 897 missense null Y897S TIE2_HUMAN/824-1092 TIE2_HUMAN 0 null 47 Activating 897 897 missense null Y323T null MK14_HUMAN 0 null 46 Activating 323 323 missense null Y323R null MK14_HUMAN 0 null 46 Activating 323 323 missense null Y323Q null MK14_HUMAN 0 null 46 Activating 323 323 missense null V678F TYK2_HUMAN/589-866 TYK2_HUMAN 0 null 46 Activating 678 678 missense null G787R EPHB2_HUMAN/621-880 EPHB2_HUMAN null null 50 Inactivating 787 787 missense null E378G SRC_HUMAN/270-519 SRC_HUMAN 0 null 51 Activating 378 378 missense null Y530* null SRC_HUMAN 0 null 51 Activating 530 530 nonsense null L747_P753>P EGFR_HUMAN/712-968 EGFR_HUMAN 0 null 13 Activating 747 753 indel null E746_T751>D EGFR_HUMAN/712-968 EGFR_HUMAN 0 null 13 Activating 746 751 indel null E865L EGFR_HUMAN/712-968 EGFR_HUMAN 0 null 13 Activating 865 865 missense null E749Q EGFR_HUMAN/712-968 EGFR_HUMAN 0 null 13 Activating 749 749 missense null E750P EGFR_HUMAN/712-968 EGFR_HUMAN 0 null 13 Activating 750 750 missense null E746_A750>P EGFR_HUMAN/712-968 EGFR_HUMAN 0.02 null 13 Activating 746 750 indel null R659S null KPCG_HUMAN 0 null 52 Activating 659 659 missense null F53S null MP2K1_HUMAN 0 null 19 Activating 53 53 missense null S218D+S222D MP2K1_HUMAN/68-361 MP2K1_HUMAN 0 null 46 Activating 218 222 missense null Y155F null KPCD_HUMAN null null 46 Inactivating 155 155 missense null K376R KPCD_HUMAN/349-603 KPCD_HUMAN null null 46 Inactivating 376 376 missense null G215D STK11_HUMAN/49-309 STK11_HUMAN null null 17 Inactivating 215 215 missense null K175_D176del STK11_HUMAN/49-309 STK11_HUMAN null null 17 Inactivating 175 176 deletion null T230P STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 230 230 missense null R304W STK11_HUMAN/49-309 STK11_HUMAN null null 17 Inactivating 304 304 missense null R86G STK11_HUMAN/49-309 STK11_HUMAN null null 15 Inactivating 86 86 missense null I303_S307del STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 303 307 deletion null T363I null STK11_HUMAN null null 17 Inactivating 363 363 missense null K108R STK11_HUMAN/49-309 STK11_HUMAN null null 17 Inactivating 108 108 missense null I177N STK11_HUMAN/49-309 STK11_HUMAN null null 17 Inactivating 177 177 missense null D176N STK11_HUMAN/49-309 STK11_HUMAN null null 17 Inactivating 176 176 missense null W308C STK11_HUMAN/49-309 STK11_HUMAN null null 17 Inactivating 308 308 missense null L67P STK11_HUMAN/49-309 STK11_HUMAN null null 17 Inactivating 67 67 missense null W239C STK11_HUMAN/49-309 STK11_HUMAN null null 17 Inactivating 239 239 missense null S232P STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 232 232 missense null I303_H306>N STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 303 306 indel null K78I STK11_HUMAN/49-309 STK11_HUMAN null null 17 Inactivating 78 78 missense null F157S STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 157 157 missense null Q137_L140del STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 137 140 deletion null K108_N109del STK11_HUMAN/49-309 STK11_HUMAN null null 17 Inactivating 108 109 deletion null Q170P STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 170 170 missense null K78A STK11_HUMAN/49-309 STK11_HUMAN null null 46 Inactivating 78 78 missense null N181E STK11_HUMAN/49-309 STK11_HUMAN null null null Inactivating 181 181 missense null Q257R null BRAF_HUMAN 0 null 19 Activating 257 257 missense null S467A BRAF_HUMAN/457-714 BRAF_HUMAN 0 null 19 Activating 467 467 missense null K499E BRAF_HUMAN/457-714 BRAF_HUMAN 0 null 19 Activating 499 499 missense null E501G BRAF_HUMAN/457-714 BRAF_HUMAN 0 null 19 Activating 501 501 missense null R1192P ALK_HUMAN/1116-1383 ALK_HUMAN 0 null 20 Activating 1192 1192 missense null I1250T ALK_HUMAN/1116-1383 ALK_HUMAN 0 null 20 Activating 1250 1250 missense null S222D+S226D MP2K2_HUMAN/72-369 MP2K2_HUMAN 0 null 46 Activating 222 226 missense null F57C null MP2K2_HUMAN 0 null 19 Activating 57 57 missense null D438Y CHK2_HUMAN/220-486 CHK2_HUMAN null null 25 Inactivating 438 438 missense null R181C null CHK2_HUMAN null null 26 Inactivating 181 181 missense null D161del null CHK2_HUMAN null null 25 Inactivating 161 161 deletion null Y390S CHK2_HUMAN/220-486 CHK2_HUMAN null null 25 Inactivating 390 390 missense null E321K CHK2_HUMAN/220-486 CHK2_HUMAN null null 26 Inactivating 321 321 missense null R145W null CHK2_HUMAN null null 25 Inactivating 145 145 missense null I251F CHK2_HUMAN/220-486 CHK2_HUMAN null null 26 Inactivating 251 251 missense null D239L CHK2_HUMAN/220-486 CHK2_HUMAN null null 26 Inactivating 239 239 missense null K224D CHK2_HUMAN/220-486 CHK2_HUMAN null null 25 Inactivating 224 224 missense null R318H CHK2_HUMAN/220-486 CHK2_HUMAN null null 26 Inactivating 318 318 missense null T323P CHK2_HUMAN/220-486 CHK2_HUMAN null null 26 Inactivating 323 323 missense null T476M CHK2_HUMAN/220-486 CHK2_HUMAN null null 25 Inactivating 476 476 missense null F590G null FLT3_HUMAN 0 null 24 Activating 590 590 missense null F594_E596 null FLT3_HUMAN 0.02 null 24 Activating 594 596 - null Y591D null FLT3_HUMAN 0 null 24 Activating 591 591 missense null K525E FGFR2_HUMAN/481-757 FGFR2_HUMAN 0.4 null 53 Activating 525 525 missense null K641R FGFR2_HUMAN/481-757 FGFR2_HUMAN 0 null 53 Activating 641 641 missense null E565A FGFR2_HUMAN/481-757 FGFR2_HUMAN 0 null 53 Activating 565 565 missense null E565G FGFR2_HUMAN/481-757 FGFR2_HUMAN 0 null 53 Activating 565 565 missense null N549T FGFR2_HUMAN/481-757 FGFR2_HUMAN 0 null 53 Activating 549 549 missense null C342Y null FGFR2_HUMAN 0 null 54 Activating 342 342 missense null D668N NTRK1_HUMAN/510-781 NTRK1_HUMAN 0 null 46 Activating 668 668 missense null P203A null NTRK1_HUMAN 0 null 46 Activating 203 203 missense null S891A RET_HUMAN/724-1005 RET_HUMAN 0 null 29 Activating 891 891 missense null Y606C null RET_HUMAN 0 null 46 Activating 606 606 missense null C634_R635insHGLC null RET_HUMAN 0 null 29 Activating 634 635 insertion null V804M+E805K RET_HUMAN/724-1005 RET_HUMAN 0.22 null 29 Activating 804 805 missense null V804L RET_HUMAN/724-1005 RET_HUMAN 0 null 29 Activating 804 804 missense null C620Y null RET_HUMAN 0 null 29 Activating 620 620 missense null E41K null BTK_HUMAN 0 null 55 Activating 41 41 missense null Y317F null KSYK_HUMAN 0 null 46 Activating 317 317 missense null K38A null FAK1_HUMAN 0 null 46 Activating 38 38 missense null K558_Y570>NP null KIT_HUMAN 0 null 9 Activating 558 570 indel null K558_Y570>R null KIT_HUMAN 0 null 9 Activating 558 570 indel null D1228N MET_HUMAN/1078-1337 MET_HUMAN 0 null 32 Activating 1228 1228 missense null P261S null RAF1_HUMAN 0 null 35 Activating 261 261 missense null P261A null RAF1_HUMAN 0 null 35 Activating 261 261 missense null P261L null RAF1_HUMAN 0 null 35 Activating 261 261 missense null T491I RAF1_HUMAN/349-606 RAF1_HUMAN 0 null 35 Activating 491 491 missense null V263A null RAF1_HUMAN 0 null 35 Activating 263 263 missense null S752_I759del EGFR_HUMAN/712-968 EGFR_HUMAN 0.242708628291736 24 13 Activating 752 759 deletion 98884 E746_A750del EGFR_HUMAN/712-968 EGFR_HUMAN 30.1565470652482 2982 13 Activating 746 750 deletion 98884 L747_P753del EGFR_HUMAN/712-968 EGFR_HUMAN 0.293272925852514 29 13 Activating 747 753 deletion 98884 L747_T751del EGFR_HUMAN/712-968 EGFR_HUMAN 1.71918611706646 170 13 Activating 747 751 deletion 98884 K745_E749del EGFR_HUMAN/712-968 EGFR_HUMAN 0.141580033170179 14 13 Activating 745 749 deletion 98884 E746_S752del EGFR_HUMAN/712-968 EGFR_HUMAN 0.161805752194491 16 13 Activating 746 752 deletion 98884 K745_A750del EGFR_HUMAN/712-968 EGFR_HUMAN 0.141580033170179 14 13 Activating 745 750 deletion 98884 R748_P753del EGFR_HUMAN/712-968 EGFR_HUMAN 0.0202257190243113 2 13 Activating 748 753 deletion 98884 L747_S752del EGFR_HUMAN/712-968 EGFR_HUMAN 0.809028760972453 80 13 Activating 747 752 deletion 98884 E746_E749del EGFR_HUMAN/712-968 EGFR_HUMAN 0.121354314145868 12 13 Activating 746 749 deletion 98884 E746_T751del EGFR_HUMAN/712-968 EGFR_HUMAN 0.293272925852514 29 13 Activating 746 751 deletion 98884 E746_R748del EGFR_HUMAN/712-968 EGFR_HUMAN 0.0101128595121557 1 13 Activating 746 748 deletion 98884 L747_E749del EGFR_HUMAN/712-968 EGFR_HUMAN 0.273047206828203 27 13 Activating 747 749 deletion 98884 I843_D846del PGFRA_HUMAN/593-950 PGFRA_HUMAN 2.22496909765142 45 9 Activating 843 846 deletion 20225 D842_M844del PGFRA_HUMAN/593-950 PGFRA_HUMAN 0.444993819530284 9 9 Activating 842 844 deletion 20225 R560_S564del null PGFRA_HUMAN 0.0988875154511743 2 9 Activating 560 564 deletion 20225 M844_S847del PGFRA_HUMAN/593-950 PGFRA_HUMAN 0.444993819530284 9 9 Activating 844 847 deletion 20225 D842_H845del PGFRA_HUMAN/593-950 PGFRA_HUMAN 1.73053152039555 35 9 Activating 842 845 deletion 20225 I836del FLT3_HUMAN/610-943 FLT3_HUMAN 0.338083844793509 26 24 Activating 836 836 deletion 76904 L182del STK11_HUMAN/49-309 STK11_HUMAN 0.144822592324403 1 4 Inactivating 182 182 deletion 6905 E98_G155del STK11_HUMAN/49-309 STK11_HUMAN 0.434467776973208 3 null Inactivating 98 155 deletion 6905 V560del null KIT_HUMAN 1.96409390823999 64 9 Activating 560 560 deletion 32585 W557_K558del null KIT_HUMAN 13.4724566518337 439 9 Activating 557 558 deletion 32585 D579del null KIT_HUMAN 2.39373945066749 78 9 Activating 579 579 deletion 32585 W557_E561del null KIT_HUMAN 1.31962559459874 43 9 Activating 557 561 deletion 32585 P551_E554del null KIT_HUMAN 0.491023477059997 16 9 Activating 551 554 deletion 32585 Y553_K558del null KIT_HUMAN 0.429645542427497 14 9 Activating 553 558 deletion 32585 K558_E562del null KIT_HUMAN 0.644468313641246 21 9 Activating 558 562 deletion 32585 P551_V555del null KIT_HUMAN 0.491023477059997 16 9 Activating 551 555 deletion 32585 Y570_L576del null KIT_HUMAN 0.583090379008746 19 9 Activating 570 576 deletion 32585 M552_Y553del null KIT_HUMAN 0.460334509743747 15 9 Activating 552 553 deletion 32585 K558_V559del null KIT_HUMAN 0.675157280957496 22 9 Activating 558 559 deletion 32585 M552_W557del null KIT_HUMAN 0.675157280957496 22 9 Activating 552 557 deletion 32585 V569_L576del null KIT_HUMAN 0.613779346324996 20 9 Activating 569 576 deletion 32585 K550_K558del null KIT_HUMAN 1.31962559459874 43 9 Activating 550 558 deletion 32585 K550_E554del null KIT_HUMAN 0.337578640478748 11 9 Activating 550 554 deletion 32585 V555_Q556del null KIT_HUMAN 0.276200705846248 9 9 Activating 555 556 deletion 32585 V560_L576del null KIT_HUMAN 0.675157280957496 22 9 Activating 560 576 deletion 32585 V559del null KIT_HUMAN 1.35031456191499 44 9 Activating 559 559 deletion 32585 V559_E561del null KIT_HUMAN 0.552401411692497 18 9 Activating 559 561 deletion 32585 M552_V555del null KIT_HUMAN 0.368267607794998 12 9 Activating 552 555 deletion 32585 Q556_W557del null KIT_HUMAN 0.429645542427497 14 9 Activating 556 557 deletion 32585 L576del null KIT_HUMAN 0.368267607794998 12 9 Activating 576 576 deletion 32585 W557_V559del null KIT_HUMAN 0.429645542427497 14 9 Activating 557 559 deletion 32585 V559_T574del null KIT_HUMAN 0.184133803897499 6 9 Activating 559 574 deletion 32585 K558_V560del null KIT_HUMAN 0.460334509743747 15 9 Activating 558 560 deletion 32585 P551_Q556del null KIT_HUMAN 0.368267607794998 12 9 Activating 551 556 deletion 32585 N567_P573del null KIT_HUMAN 0.184133803897499 6 9 Activating 567 573 deletion 32585 V555_V559del null KIT_HUMAN 0.245511738529998 8 9 Activating 555 559 deletion 32585 Q556_V559del null KIT_HUMAN 0.184133803897499 6 9 Activating 556 559 deletion 32585 E554_K558del null KIT_HUMAN 0.951357986803744 31 9 Activating 554 558 deletion 32585 M552_D572del null KIT_HUMAN 0.122755869264999 4 9 Activating 552 572 deletion 32585 N564_L576del null KIT_HUMAN 0.429645542427497 14 9 Activating 564 576 deletion 32585 Y553_Q556del null KIT_HUMAN 0.398956575111247 13 9 Activating 553 556 deletion 32585 V559_G565del null KIT_HUMAN 0.460334509743747 15 9 Activating 559 565 deletion 32585 K558_D572del null KIT_HUMAN 0.276200705846248 9 9 Activating 558 572 deletion 32585 E632_L633del null RET_HUMAN 0.511334583262315 9 29 Activating 632 633 deletion 17601 N542_E543del null JAK2_HUMAN 0.622873844089885 65 12 Activating 542 543 deletion 104355 E543_D544del null JAK2_HUMAN 0.287480235733793 30 12 Activating 543 544 deletion 104355